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Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012
BACKGROUND: To understand the prevalence and characteristics of human cytomegalovirus (HCMV) infection in children in the Weifang area, and to provide information for its prevention and treatment. METHODS: A comprehensive survey was performed from 2009 to 2012 in 7582 children from birth to 6 years...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599997/ https://www.ncbi.nlm.nih.gov/pubmed/23369640 http://dx.doi.org/10.1186/1743-422X-10-42 |
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author | Sun, Xiuning Liu, Zhijun Wang, Bin Shi, Lihong Liang, Ruiwen Li, Ling |
author_facet | Sun, Xiuning Liu, Zhijun Wang, Bin Shi, Lihong Liang, Ruiwen Li, Ling |
author_sort | Sun, Xiuning |
collection | PubMed |
description | BACKGROUND: To understand the prevalence and characteristics of human cytomegalovirus (HCMV) infection in children in the Weifang area, and to provide information for its prevention and treatment. METHODS: A comprehensive survey was performed from 2009 to 2012 in 7582 children from birth to 6 years of age hospitalized in the Maternity and Child Health Hospital of Weifang. ELISA HCMV serology results and survey data were analyzed by age group and socio-economic level. The infection rates were based on IgG and IgM serology. RESULTS AND CONCLUSIONS: The overall infection rate from IgG and IgM in the Weifang area from 2009 to 2012 was 42.5% (3496/7582), among which 34.2% were HCMV-IgG positive, suggesting past infection. Overall, the probability of active HCMV infection showed no gender difference in any age group (P >0.05). Recent infections centered on the first 6 months of life, presumably due to breastfeeding. Among the 654 children hospitalized for active HCMV infection, 379 (57.9%) were from rural areas and 275 (42.1%) from urban areas, showing that active infection in the countryside was higher than that in the city (χ(2) = 32.65, p <0.01). |
format | Online Article Text |
id | pubmed-3599997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35999972013-03-17 Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012 Sun, Xiuning Liu, Zhijun Wang, Bin Shi, Lihong Liang, Ruiwen Li, Ling Virol J Research BACKGROUND: To understand the prevalence and characteristics of human cytomegalovirus (HCMV) infection in children in the Weifang area, and to provide information for its prevention and treatment. METHODS: A comprehensive survey was performed from 2009 to 2012 in 7582 children from birth to 6 years of age hospitalized in the Maternity and Child Health Hospital of Weifang. ELISA HCMV serology results and survey data were analyzed by age group and socio-economic level. The infection rates were based on IgG and IgM serology. RESULTS AND CONCLUSIONS: The overall infection rate from IgG and IgM in the Weifang area from 2009 to 2012 was 42.5% (3496/7582), among which 34.2% were HCMV-IgG positive, suggesting past infection. Overall, the probability of active HCMV infection showed no gender difference in any age group (P >0.05). Recent infections centered on the first 6 months of life, presumably due to breastfeeding. Among the 654 children hospitalized for active HCMV infection, 379 (57.9%) were from rural areas and 275 (42.1%) from urban areas, showing that active infection in the countryside was higher than that in the city (χ(2) = 32.65, p <0.01). BioMed Central 2013-02-01 /pmc/articles/PMC3599997/ /pubmed/23369640 http://dx.doi.org/10.1186/1743-422X-10-42 Text en Copyright ©2013 Sun et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Sun, Xiuning Liu, Zhijun Wang, Bin Shi, Lihong Liang, Ruiwen Li, Ling Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012 |
title | Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012 |
title_full | Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012 |
title_fullStr | Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012 |
title_full_unstemmed | Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012 |
title_short | Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012 |
title_sort | sero-epidemiological survey of human cytomegalovirus-infected children in weifang (eastern china) between 2009 and 2012 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599997/ https://www.ncbi.nlm.nih.gov/pubmed/23369640 http://dx.doi.org/10.1186/1743-422X-10-42 |
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