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Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China
BACKGROUND: According to the Lauren classification, gastric adenocarcinomas are divided into diffuse and intestinal types. The causative attribution explaining the dismal prognosis of diffuse-type remains unknown. METHODS: We examined the archive of 1000 patients with gastric adenocarcinomas who rec...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600019/ https://www.ncbi.nlm.nih.gov/pubmed/23497313 http://dx.doi.org/10.1186/1479-5876-11-58 |
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author | Qiu, Miao-zhen Cai, Mu-yan Zhang, Dong-sheng Wang, Zhi-qiang Wang, De-shen Li, Yu-hong Xu, Rui-hua |
author_facet | Qiu, Miao-zhen Cai, Mu-yan Zhang, Dong-sheng Wang, Zhi-qiang Wang, De-shen Li, Yu-hong Xu, Rui-hua |
author_sort | Qiu, Miao-zhen |
collection | PubMed |
description | BACKGROUND: According to the Lauren classification, gastric adenocarcinomas are divided into diffuse and intestinal types. The causative attribution explaining the dismal prognosis of diffuse-type remains unknown. METHODS: We examined the archive of 1000 patients with gastric adenocarcinomas who received radical gastrectomy in our center and assessed the effect of the Lauren classification on survival in a multivariate approach. Moreover we compared the variation of clinical features between the diffuse-type and intestinal-type and explored the contributing factors for the prognostic difference. RESULTS: There were 805 resectable patients for the final analysis. Diffuse-type comprised of 48.7% in the gastric carcinoma in our group and showed poorer prognosis than intestinal-type (P=0.013). Multivariate analysis revealed that independent prognostic factors for gastric carcinoma patients were T stage (P<0.001), N stage (P<0.001) tumor size (P<0.001) and Lauren classification (P=0.003). For the clinical features, diffuse-type was significantly associated with younger age (p<0.001), female preponderance (p <0.001), distal location (P<0.001), advanced pT (p < 0.001), advanced pN (p < 0.001) and advanced TNM stage (p = 0.027). CONCLUSIONS: Diffuse type adenocarcinoma carries a worse prognosis that may be partially explained by the tendency of this subtype to present at more advanced T and N stage. However, Lauren classification has prognostic significance that is independent of T and N stage as well as other prognostic variables based on the multivariate cox analysis. |
format | Online Article Text |
id | pubmed-3600019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36000192013-03-17 Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China Qiu, Miao-zhen Cai, Mu-yan Zhang, Dong-sheng Wang, Zhi-qiang Wang, De-shen Li, Yu-hong Xu, Rui-hua J Transl Med Research BACKGROUND: According to the Lauren classification, gastric adenocarcinomas are divided into diffuse and intestinal types. The causative attribution explaining the dismal prognosis of diffuse-type remains unknown. METHODS: We examined the archive of 1000 patients with gastric adenocarcinomas who received radical gastrectomy in our center and assessed the effect of the Lauren classification on survival in a multivariate approach. Moreover we compared the variation of clinical features between the diffuse-type and intestinal-type and explored the contributing factors for the prognostic difference. RESULTS: There were 805 resectable patients for the final analysis. Diffuse-type comprised of 48.7% in the gastric carcinoma in our group and showed poorer prognosis than intestinal-type (P=0.013). Multivariate analysis revealed that independent prognostic factors for gastric carcinoma patients were T stage (P<0.001), N stage (P<0.001) tumor size (P<0.001) and Lauren classification (P=0.003). For the clinical features, diffuse-type was significantly associated with younger age (p<0.001), female preponderance (p <0.001), distal location (P<0.001), advanced pT (p < 0.001), advanced pN (p < 0.001) and advanced TNM stage (p = 0.027). CONCLUSIONS: Diffuse type adenocarcinoma carries a worse prognosis that may be partially explained by the tendency of this subtype to present at more advanced T and N stage. However, Lauren classification has prognostic significance that is independent of T and N stage as well as other prognostic variables based on the multivariate cox analysis. BioMed Central 2013-03-06 /pmc/articles/PMC3600019/ /pubmed/23497313 http://dx.doi.org/10.1186/1479-5876-11-58 Text en Copyright ©2013 Qiu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Qiu, Miao-zhen Cai, Mu-yan Zhang, Dong-sheng Wang, Zhi-qiang Wang, De-shen Li, Yu-hong Xu, Rui-hua Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China |
title | Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China |
title_full | Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China |
title_fullStr | Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China |
title_full_unstemmed | Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China |
title_short | Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China |
title_sort | clinicopathological characteristics and prognostic analysis of lauren classification in gastric adenocarcinoma in china |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600019/ https://www.ncbi.nlm.nih.gov/pubmed/23497313 http://dx.doi.org/10.1186/1479-5876-11-58 |
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