The TWEAK Receptor Fn14 is a Novel Therapeutic Target in Melanoma: Immunotoxins Targeting Fn14 Receptor for Malignant Melanoma Treatment

Fn14, the cell surface receptor for TWEAK, is over-expressed in various human solid tumor types and can be a negative prognostic indicator. We detected Fn14 expression in ~60% of the melanoma cell lines we tested, including both B-Raf WT and B-Raf(V600E) lines. Tumor tissue microarray analysis indic...

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Detalles Bibliográficos
Autores principales: Zhou, Hong, Ekmekcioglu, Suhendan, Marks, John W., Mohamedali, Khalid A., Asrani, Kaushal, Phillips, Keeley K., Brown, Sharron A.N., Cheng, Emily, Weiss, Michele B., Hittelman, Walter N., Tran, Nhan L., Yagita, Hideo, Winkles, Jeffrey A., Rosenblum, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600159/
https://www.ncbi.nlm.nih.gov/pubmed/23190886
http://dx.doi.org/10.1038/jid.2012.402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600159/
https://www.ncbi.nlm.nih.gov/pubmed/23190886
http://dx.doi.org/10.1038/jid.2012.402

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