Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer

The relation between HPV and head and neck cancer has recently and extensively been investigated. The purpose of this study was to indentify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33 and 45) in oral squamous cell carcinomas (OSCCs) from 45 Greek patients. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Kouvousi, Maria, Xesfyngi, Dimitra, Tsimplaki, Elpida, Argyri, Elena, Ioannidou, Georgia, Ploxorou, Maria, Lazaris, Andreas C., Patsouris, Efstratios, Panotopoulou, Efstathia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600178/
https://www.ncbi.nlm.nih.gov/pubmed/23533409
http://dx.doi.org/10.1155/2013/756510
_version_ 1782475598910717952
author Kouvousi, Maria
Xesfyngi, Dimitra
Tsimplaki, Elpida
Argyri, Elena
Ioannidou, Georgia
Ploxorou, Maria
Lazaris, Andreas C.
Patsouris, Efstratios
Panotopoulou, Efstathia
author_facet Kouvousi, Maria
Xesfyngi, Dimitra
Tsimplaki, Elpida
Argyri, Elena
Ioannidou, Georgia
Ploxorou, Maria
Lazaris, Andreas C.
Patsouris, Efstratios
Panotopoulou, Efstathia
author_sort Kouvousi, Maria
collection PubMed
description The relation between HPV and head and neck cancer has recently and extensively been investigated. The purpose of this study was to indentify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33 and 45) in oral squamous cell carcinomas (OSCCs) from 45 Greek patients. The overall prevalence of HPV DNA positive OSCCs was 11.1% (5/45), while high-risk HPV DNA was found in 6.7% (3/45) of OSCCs. E6/E7 mRNA expression was detected in 8.9% (4/45) of the oral cavity samples. Our data indicated that HPV 16 was the commonest genotype identified in HPV-positive OSCCs by both DNA and RNA tests. This study confirms the prevalence of HPV infections among patients with OSCCs. Future analysis and followup of more OSCCs will enable us to correlate HPV detection and clinical outcome.
format Online
Article
Text
id pubmed-3600178
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36001782013-03-26 Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer Kouvousi, Maria Xesfyngi, Dimitra Tsimplaki, Elpida Argyri, Elena Ioannidou, Georgia Ploxorou, Maria Lazaris, Andreas C. Patsouris, Efstratios Panotopoulou, Efstathia J Oncol Research Article The relation between HPV and head and neck cancer has recently and extensively been investigated. The purpose of this study was to indentify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33 and 45) in oral squamous cell carcinomas (OSCCs) from 45 Greek patients. The overall prevalence of HPV DNA positive OSCCs was 11.1% (5/45), while high-risk HPV DNA was found in 6.7% (3/45) of OSCCs. E6/E7 mRNA expression was detected in 8.9% (4/45) of the oral cavity samples. Our data indicated that HPV 16 was the commonest genotype identified in HPV-positive OSCCs by both DNA and RNA tests. This study confirms the prevalence of HPV infections among patients with OSCCs. Future analysis and followup of more OSCCs will enable us to correlate HPV detection and clinical outcome. Hindawi Publishing Corporation 2013 2013-02-27 /pmc/articles/PMC3600178/ /pubmed/23533409 http://dx.doi.org/10.1155/2013/756510 Text en Copyright © 2013 Maria Kouvousi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kouvousi, Maria
Xesfyngi, Dimitra
Tsimplaki, Elpida
Argyri, Elena
Ioannidou, Georgia
Ploxorou, Maria
Lazaris, Andreas C.
Patsouris, Efstratios
Panotopoulou, Efstathia
Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer
title Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer
title_full Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer
title_fullStr Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer
title_full_unstemmed Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer
title_short Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer
title_sort prevalence of human papillomavirus in 45 greek patients with oral cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600178/
https://www.ncbi.nlm.nih.gov/pubmed/23533409
http://dx.doi.org/10.1155/2013/756510
work_keys_str_mv AT kouvousimaria prevalenceofhumanpapillomavirusin45greekpatientswithoralcancer
AT xesfyngidimitra prevalenceofhumanpapillomavirusin45greekpatientswithoralcancer
AT tsimplakielpida prevalenceofhumanpapillomavirusin45greekpatientswithoralcancer
AT argyrielena prevalenceofhumanpapillomavirusin45greekpatientswithoralcancer
AT ioannidougeorgia prevalenceofhumanpapillomavirusin45greekpatientswithoralcancer
AT ploxoroumaria prevalenceofhumanpapillomavirusin45greekpatientswithoralcancer
AT lazarisandreasc prevalenceofhumanpapillomavirusin45greekpatientswithoralcancer
AT patsourisefstratios prevalenceofhumanpapillomavirusin45greekpatientswithoralcancer
AT panotopoulouefstathia prevalenceofhumanpapillomavirusin45greekpatientswithoralcancer

Ejemplares similares