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Macrophage Heterogeneity in Respiratory Diseases
Macrophages are among the most abundant cells in the respiratory tract, and they can have strikingly different phenotypes within this environment. Our knowledge of the different phenotypes and their functions in the lung is sketchy at best, but they appear to be linked to the protection of gas excha...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600198/ https://www.ncbi.nlm.nih.gov/pubmed/23533311 http://dx.doi.org/10.1155/2013/769214 |
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author | Boorsma, Carian E. Draijer, Christina Melgert, Barbro N. |
author_facet | Boorsma, Carian E. Draijer, Christina Melgert, Barbro N. |
author_sort | Boorsma, Carian E. |
collection | PubMed |
description | Macrophages are among the most abundant cells in the respiratory tract, and they can have strikingly different phenotypes within this environment. Our knowledge of the different phenotypes and their functions in the lung is sketchy at best, but they appear to be linked to the protection of gas exchange against microbial threats and excessive tissue responses. Phenotypical changes of macrophages within the lung are found in many respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. This paper will give an overview of what macrophage phenotypes have been described, what their known functions are, what is known about their presence in the different obstructive and restrictive respiratory diseases (asthma, COPD, pulmonary fibrosis), and how they are thought to contribute to the etiology and resolution of these diseases. |
format | Online Article Text |
id | pubmed-3600198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36001982013-03-26 Macrophage Heterogeneity in Respiratory Diseases Boorsma, Carian E. Draijer, Christina Melgert, Barbro N. Mediators Inflamm Review Article Macrophages are among the most abundant cells in the respiratory tract, and they can have strikingly different phenotypes within this environment. Our knowledge of the different phenotypes and their functions in the lung is sketchy at best, but they appear to be linked to the protection of gas exchange against microbial threats and excessive tissue responses. Phenotypical changes of macrophages within the lung are found in many respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. This paper will give an overview of what macrophage phenotypes have been described, what their known functions are, what is known about their presence in the different obstructive and restrictive respiratory diseases (asthma, COPD, pulmonary fibrosis), and how they are thought to contribute to the etiology and resolution of these diseases. Hindawi Publishing Corporation 2013 2013-02-27 /pmc/articles/PMC3600198/ /pubmed/23533311 http://dx.doi.org/10.1155/2013/769214 Text en Copyright © 2013 Carian E. Boorsma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Boorsma, Carian E. Draijer, Christina Melgert, Barbro N. Macrophage Heterogeneity in Respiratory Diseases |
title | Macrophage Heterogeneity in Respiratory Diseases |
title_full | Macrophage Heterogeneity in Respiratory Diseases |
title_fullStr | Macrophage Heterogeneity in Respiratory Diseases |
title_full_unstemmed | Macrophage Heterogeneity in Respiratory Diseases |
title_short | Macrophage Heterogeneity in Respiratory Diseases |
title_sort | macrophage heterogeneity in respiratory diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600198/ https://www.ncbi.nlm.nih.gov/pubmed/23533311 http://dx.doi.org/10.1155/2013/769214 |
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