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Roles of γ δ T Cells in the Pathogenesis of Autoimmune Diseases

γ δ T cells are a minor population of T cells that express the TCR γ δ chains, mainly distributed in the mucosal and epithelial tissue and accounting for less than 5% of the total T cells in the peripheral blood. By bridging innate and adaptive immunity, γ δ T cells play important roles in the anti-...

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Detalles Bibliográficos
Autores principales: Su, Dinglei, Shen, Minning, Li, Xia, Sun, Lingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600234/
https://www.ncbi.nlm.nih.gov/pubmed/23533458
http://dx.doi.org/10.1155/2013/985753
Descripción
Sumario:γ δ T cells are a minor population of T cells that express the TCR γ δ chains, mainly distributed in the mucosal and epithelial tissue and accounting for less than 5% of the total T cells in the peripheral blood. By bridging innate and adaptive immunity, γ δ T cells play important roles in the anti-infection, antitumor, and autoimmune responses. Previous research on γ δ T cells was primarily concentrated on infectious diseases and tumors, whereas their functions in autoimmune diseases attracted much attention. In this paper, we summarized the various functions of γ δ T cells in two prototypical autoimmune connective tissue diseases, that is, SLE and RA, elaborating on their antigen-presenting capacity, secretion of proinflammatory cytokines, immunomodulatory effects, and auxiliary function for B cells, which contribute to overproduction of proinflammatory cytokines and pathogenic autoantibodies, ultimately leading to the onset of these autoimmune diseases. Elucidation of the roles of γ δ T cells in autoimmune diseases is not only conducive to in-depth understanding of the pathogenesis of these diseases, but also beneficial in providing theoretical support for the development of γ δ T-cell-targeted therapy.