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Vasculogenic Cytokines in Wound Healing

Chronic wounds represent a growing healthcare burden that particularly afflicts aged, diabetic, vasculopathic, and obese patients. Studies have shown that nonhealing wounds are characterized by dysregulated cytokine networks that impair blood vessel formation. Two distinct forms of neovascularizatio...

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Detalles Bibliográficos
Autores principales: Wong, Victor W., Crawford, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600243/
https://www.ncbi.nlm.nih.gov/pubmed/23555076
http://dx.doi.org/10.1155/2013/190486
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author Wong, Victor W.
Crawford, Jeffrey D.
author_facet Wong, Victor W.
Crawford, Jeffrey D.
author_sort Wong, Victor W.
collection PubMed
description Chronic wounds represent a growing healthcare burden that particularly afflicts aged, diabetic, vasculopathic, and obese patients. Studies have shown that nonhealing wounds are characterized by dysregulated cytokine networks that impair blood vessel formation. Two distinct forms of neovascularization have been described: vasculogenesis (driven by bone-marrow-derived circulating endothelial progenitor cells) and angiogenesis (local endothelial cell sprouting from existing vasculature). Researchers have traditionally focused on angiogenesis but defects in vasculogenesis are increasingly recognized to impact diseases including wound healing. A more comprehensive understanding of vasculogenic cytokine networks may facilitate the development of novel strategies to treat recalcitrant wounds. Further, the clinical success of endothelial progenitor cell-based therapies will depend not only on the delivery of the cells themselves but also on the appropriate cytokine milieu to promote tissue regeneration. This paper will highlight major cytokines involved in vasculogenesis within the context of cutaneous wound healing.
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spelling pubmed-36002432013-04-02 Vasculogenic Cytokines in Wound Healing Wong, Victor W. Crawford, Jeffrey D. Biomed Res Int Review Article Chronic wounds represent a growing healthcare burden that particularly afflicts aged, diabetic, vasculopathic, and obese patients. Studies have shown that nonhealing wounds are characterized by dysregulated cytokine networks that impair blood vessel formation. Two distinct forms of neovascularization have been described: vasculogenesis (driven by bone-marrow-derived circulating endothelial progenitor cells) and angiogenesis (local endothelial cell sprouting from existing vasculature). Researchers have traditionally focused on angiogenesis but defects in vasculogenesis are increasingly recognized to impact diseases including wound healing. A more comprehensive understanding of vasculogenic cytokine networks may facilitate the development of novel strategies to treat recalcitrant wounds. Further, the clinical success of endothelial progenitor cell-based therapies will depend not only on the delivery of the cells themselves but also on the appropriate cytokine milieu to promote tissue regeneration. This paper will highlight major cytokines involved in vasculogenesis within the context of cutaneous wound healing. Hindawi Publishing Corporation 2013 2013-02-28 /pmc/articles/PMC3600243/ /pubmed/23555076 http://dx.doi.org/10.1155/2013/190486 Text en Copyright © 2013 V. W. Wong and J. D. Crawford. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wong, Victor W.
Crawford, Jeffrey D.
Vasculogenic Cytokines in Wound Healing
title Vasculogenic Cytokines in Wound Healing
title_full Vasculogenic Cytokines in Wound Healing
title_fullStr Vasculogenic Cytokines in Wound Healing
title_full_unstemmed Vasculogenic Cytokines in Wound Healing
title_short Vasculogenic Cytokines in Wound Healing
title_sort vasculogenic cytokines in wound healing
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600243/
https://www.ncbi.nlm.nih.gov/pubmed/23555076
http://dx.doi.org/10.1155/2013/190486
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