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Vasculogenic Cytokines in Wound Healing
Chronic wounds represent a growing healthcare burden that particularly afflicts aged, diabetic, vasculopathic, and obese patients. Studies have shown that nonhealing wounds are characterized by dysregulated cytokine networks that impair blood vessel formation. Two distinct forms of neovascularizatio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600243/ https://www.ncbi.nlm.nih.gov/pubmed/23555076 http://dx.doi.org/10.1155/2013/190486 |
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author | Wong, Victor W. Crawford, Jeffrey D. |
author_facet | Wong, Victor W. Crawford, Jeffrey D. |
author_sort | Wong, Victor W. |
collection | PubMed |
description | Chronic wounds represent a growing healthcare burden that particularly afflicts aged, diabetic, vasculopathic, and obese patients. Studies have shown that nonhealing wounds are characterized by dysregulated cytokine networks that impair blood vessel formation. Two distinct forms of neovascularization have been described: vasculogenesis (driven by bone-marrow-derived circulating endothelial progenitor cells) and angiogenesis (local endothelial cell sprouting from existing vasculature). Researchers have traditionally focused on angiogenesis but defects in vasculogenesis are increasingly recognized to impact diseases including wound healing. A more comprehensive understanding of vasculogenic cytokine networks may facilitate the development of novel strategies to treat recalcitrant wounds. Further, the clinical success of endothelial progenitor cell-based therapies will depend not only on the delivery of the cells themselves but also on the appropriate cytokine milieu to promote tissue regeneration. This paper will highlight major cytokines involved in vasculogenesis within the context of cutaneous wound healing. |
format | Online Article Text |
id | pubmed-3600243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36002432013-04-02 Vasculogenic Cytokines in Wound Healing Wong, Victor W. Crawford, Jeffrey D. Biomed Res Int Review Article Chronic wounds represent a growing healthcare burden that particularly afflicts aged, diabetic, vasculopathic, and obese patients. Studies have shown that nonhealing wounds are characterized by dysregulated cytokine networks that impair blood vessel formation. Two distinct forms of neovascularization have been described: vasculogenesis (driven by bone-marrow-derived circulating endothelial progenitor cells) and angiogenesis (local endothelial cell sprouting from existing vasculature). Researchers have traditionally focused on angiogenesis but defects in vasculogenesis are increasingly recognized to impact diseases including wound healing. A more comprehensive understanding of vasculogenic cytokine networks may facilitate the development of novel strategies to treat recalcitrant wounds. Further, the clinical success of endothelial progenitor cell-based therapies will depend not only on the delivery of the cells themselves but also on the appropriate cytokine milieu to promote tissue regeneration. This paper will highlight major cytokines involved in vasculogenesis within the context of cutaneous wound healing. Hindawi Publishing Corporation 2013 2013-02-28 /pmc/articles/PMC3600243/ /pubmed/23555076 http://dx.doi.org/10.1155/2013/190486 Text en Copyright © 2013 V. W. Wong and J. D. Crawford. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wong, Victor W. Crawford, Jeffrey D. Vasculogenic Cytokines in Wound Healing |
title | Vasculogenic Cytokines in Wound Healing |
title_full | Vasculogenic Cytokines in Wound Healing |
title_fullStr | Vasculogenic Cytokines in Wound Healing |
title_full_unstemmed | Vasculogenic Cytokines in Wound Healing |
title_short | Vasculogenic Cytokines in Wound Healing |
title_sort | vasculogenic cytokines in wound healing |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600243/ https://www.ncbi.nlm.nih.gov/pubmed/23555076 http://dx.doi.org/10.1155/2013/190486 |
work_keys_str_mv | AT wongvictorw vasculogeniccytokinesinwoundhealing AT crawfordjeffreyd vasculogeniccytokinesinwoundhealing |