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Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species
We have recently reported a potential alternative tumor suppressor function for p16 relating to its capacity to regulate oxidative stress and observed that oxidative dysregulation in p16-depleted cells was most profound in melanocytes, compared to keratinocytes or fibroblasts. Moreover, in the absen...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600250/ https://www.ncbi.nlm.nih.gov/pubmed/23555101 http://dx.doi.org/10.1155/2013/908797 |
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author | Jenkins, Noah C. Grossman, Douglas |
author_facet | Jenkins, Noah C. Grossman, Douglas |
author_sort | Jenkins, Noah C. |
collection | PubMed |
description | We have recently reported a potential alternative tumor suppressor function for p16 relating to its capacity to regulate oxidative stress and observed that oxidative dysregulation in p16-depleted cells was most profound in melanocytes, compared to keratinocytes or fibroblasts. Moreover, in the absence of p16 depletion or exogenous oxidative insult, melanocytes exhibited significantly higher basal levels of reactive oxygen species (ROS) than these other epidermal cell types. Given the role of oxidative stress in melanoma development, we speculated that this increased susceptibility of melanocytes to oxidative stress (and greater reliance on p16 for suppression of ROS) may explain why genetic compromise of p16 is more commonly associated with predisposition to melanoma rather than other cancers. Here we show that the presence of melanin accounts for this differential oxidative stress in normal and p16-depleted melanocytes. Thus the presence of melanin in the skin appears to be a double-edged sword: it protects melanocytes as well as neighboring keratinocytes in the skin through its capacity to absorb UV radiation, but its synthesis in melanocytes results in higher levels of intracellular ROS that may increase melanoma susceptibility. |
format | Online Article Text |
id | pubmed-3600250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36002502013-04-02 Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species Jenkins, Noah C. Grossman, Douglas Biomed Res Int Research Article We have recently reported a potential alternative tumor suppressor function for p16 relating to its capacity to regulate oxidative stress and observed that oxidative dysregulation in p16-depleted cells was most profound in melanocytes, compared to keratinocytes or fibroblasts. Moreover, in the absence of p16 depletion or exogenous oxidative insult, melanocytes exhibited significantly higher basal levels of reactive oxygen species (ROS) than these other epidermal cell types. Given the role of oxidative stress in melanoma development, we speculated that this increased susceptibility of melanocytes to oxidative stress (and greater reliance on p16 for suppression of ROS) may explain why genetic compromise of p16 is more commonly associated with predisposition to melanoma rather than other cancers. Here we show that the presence of melanin accounts for this differential oxidative stress in normal and p16-depleted melanocytes. Thus the presence of melanin in the skin appears to be a double-edged sword: it protects melanocytes as well as neighboring keratinocytes in the skin through its capacity to absorb UV radiation, but its synthesis in melanocytes results in higher levels of intracellular ROS that may increase melanoma susceptibility. Hindawi Publishing Corporation 2013 2013-02-28 /pmc/articles/PMC3600250/ /pubmed/23555101 http://dx.doi.org/10.1155/2013/908797 Text en Copyright © 2013 N. C. Jenkins and D. Grossman. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jenkins, Noah C. Grossman, Douglas Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species |
title | Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species |
title_full | Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species |
title_fullStr | Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species |
title_full_unstemmed | Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species |
title_short | Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species |
title_sort | role of melanin in melanocyte dysregulation of reactive oxygen species |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600250/ https://www.ncbi.nlm.nih.gov/pubmed/23555101 http://dx.doi.org/10.1155/2013/908797 |
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