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Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis

Iron status is the result of the balance between the rate of erythropoiesis and the amount of the iron stores. Direct consequence of an imbalance between the erythroid marrow iron requirements and the actual supply is a reduction of red cell hemoglobin content, which causes hypochromic mature red ce...

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Autores principales: Urrechaga, Eloísa, Borque, Luís, Escanero, Jesús F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600252/
https://www.ncbi.nlm.nih.gov/pubmed/23555091
http://dx.doi.org/10.1155/2013/603786
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author Urrechaga, Eloísa
Borque, Luís
Escanero, Jesús F.
author_facet Urrechaga, Eloísa
Borque, Luís
Escanero, Jesús F.
author_sort Urrechaga, Eloísa
collection PubMed
description Iron status is the result of the balance between the rate of erythropoiesis and the amount of the iron stores. Direct consequence of an imbalance between the erythroid marrow iron requirements and the actual supply is a reduction of red cell hemoglobin content, which causes hypochromic mature red cells and reticulocytes. The diagnosis of iron deficiency is particularly challenging in patients with acute or chronic inflammatory conditions because most of the biochemical markers for iron metabolism (serum ferritin and transferrin ) are affected by acute phase reaction. For these reasons, interest has been generated in the use of erythrocyte and reticulocyte parameters, available on the modern hematology analyzers. Reported during blood analysis routinely performed on the instrument, these parameters can assist in early detection of clinical conditions (iron deficiency, absolute, or functional; ineffective erythropoiesis, including iron restricted or thalassemia), without additional cost. Technological progress has meant that in recent years modern analyzers report new parameters that provide further information from the traditional count. Nevertheless these new parameters are exclusive of each manufacturer, and they are patented. This is an update of these new laboratory test biomarkers of hypochromia reported by different manufactures, their meaning, and clinical utility on daily practice.
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spelling pubmed-36002522013-04-02 Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis Urrechaga, Eloísa Borque, Luís Escanero, Jesús F. Biomed Res Int Review Article Iron status is the result of the balance between the rate of erythropoiesis and the amount of the iron stores. Direct consequence of an imbalance between the erythroid marrow iron requirements and the actual supply is a reduction of red cell hemoglobin content, which causes hypochromic mature red cells and reticulocytes. The diagnosis of iron deficiency is particularly challenging in patients with acute or chronic inflammatory conditions because most of the biochemical markers for iron metabolism (serum ferritin and transferrin ) are affected by acute phase reaction. For these reasons, interest has been generated in the use of erythrocyte and reticulocyte parameters, available on the modern hematology analyzers. Reported during blood analysis routinely performed on the instrument, these parameters can assist in early detection of clinical conditions (iron deficiency, absolute, or functional; ineffective erythropoiesis, including iron restricted or thalassemia), without additional cost. Technological progress has meant that in recent years modern analyzers report new parameters that provide further information from the traditional count. Nevertheless these new parameters are exclusive of each manufacturer, and they are patented. This is an update of these new laboratory test biomarkers of hypochromia reported by different manufactures, their meaning, and clinical utility on daily practice. Hindawi Publishing Corporation 2013 2013-02-28 /pmc/articles/PMC3600252/ /pubmed/23555091 http://dx.doi.org/10.1155/2013/603786 Text en Copyright © 2013 Eloísa Urrechaga et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Urrechaga, Eloísa
Borque, Luís
Escanero, Jesús F.
Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis
title Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis
title_full Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis
title_fullStr Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis
title_full_unstemmed Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis
title_short Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis
title_sort biomarkers of hypochromia: the contemporary assessment of iron status and erythropoiesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600252/
https://www.ncbi.nlm.nih.gov/pubmed/23555091
http://dx.doi.org/10.1155/2013/603786
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