Cargando…
Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis
Iron status is the result of the balance between the rate of erythropoiesis and the amount of the iron stores. Direct consequence of an imbalance between the erythroid marrow iron requirements and the actual supply is a reduction of red cell hemoglobin content, which causes hypochromic mature red ce...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600252/ https://www.ncbi.nlm.nih.gov/pubmed/23555091 http://dx.doi.org/10.1155/2013/603786 |
_version_ | 1782475615111217152 |
---|---|
author | Urrechaga, Eloísa Borque, Luís Escanero, Jesús F. |
author_facet | Urrechaga, Eloísa Borque, Luís Escanero, Jesús F. |
author_sort | Urrechaga, Eloísa |
collection | PubMed |
description | Iron status is the result of the balance between the rate of erythropoiesis and the amount of the iron stores. Direct consequence of an imbalance between the erythroid marrow iron requirements and the actual supply is a reduction of red cell hemoglobin content, which causes hypochromic mature red cells and reticulocytes. The diagnosis of iron deficiency is particularly challenging in patients with acute or chronic inflammatory conditions because most of the biochemical markers for iron metabolism (serum ferritin and transferrin ) are affected by acute phase reaction. For these reasons, interest has been generated in the use of erythrocyte and reticulocyte parameters, available on the modern hematology analyzers. Reported during blood analysis routinely performed on the instrument, these parameters can assist in early detection of clinical conditions (iron deficiency, absolute, or functional; ineffective erythropoiesis, including iron restricted or thalassemia), without additional cost. Technological progress has meant that in recent years modern analyzers report new parameters that provide further information from the traditional count. Nevertheless these new parameters are exclusive of each manufacturer, and they are patented. This is an update of these new laboratory test biomarkers of hypochromia reported by different manufactures, their meaning, and clinical utility on daily practice. |
format | Online Article Text |
id | pubmed-3600252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36002522013-04-02 Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis Urrechaga, Eloísa Borque, Luís Escanero, Jesús F. Biomed Res Int Review Article Iron status is the result of the balance between the rate of erythropoiesis and the amount of the iron stores. Direct consequence of an imbalance between the erythroid marrow iron requirements and the actual supply is a reduction of red cell hemoglobin content, which causes hypochromic mature red cells and reticulocytes. The diagnosis of iron deficiency is particularly challenging in patients with acute or chronic inflammatory conditions because most of the biochemical markers for iron metabolism (serum ferritin and transferrin ) are affected by acute phase reaction. For these reasons, interest has been generated in the use of erythrocyte and reticulocyte parameters, available on the modern hematology analyzers. Reported during blood analysis routinely performed on the instrument, these parameters can assist in early detection of clinical conditions (iron deficiency, absolute, or functional; ineffective erythropoiesis, including iron restricted or thalassemia), without additional cost. Technological progress has meant that in recent years modern analyzers report new parameters that provide further information from the traditional count. Nevertheless these new parameters are exclusive of each manufacturer, and they are patented. This is an update of these new laboratory test biomarkers of hypochromia reported by different manufactures, their meaning, and clinical utility on daily practice. Hindawi Publishing Corporation 2013 2013-02-28 /pmc/articles/PMC3600252/ /pubmed/23555091 http://dx.doi.org/10.1155/2013/603786 Text en Copyright © 2013 Eloísa Urrechaga et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Urrechaga, Eloísa Borque, Luís Escanero, Jesús F. Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis |
title | Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis |
title_full | Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis |
title_fullStr | Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis |
title_full_unstemmed | Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis |
title_short | Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis |
title_sort | biomarkers of hypochromia: the contemporary assessment of iron status and erythropoiesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600252/ https://www.ncbi.nlm.nih.gov/pubmed/23555091 http://dx.doi.org/10.1155/2013/603786 |
work_keys_str_mv | AT urrechagaeloisa biomarkersofhypochromiathecontemporaryassessmentofironstatusanderythropoiesis AT borqueluis biomarkersofhypochromiathecontemporaryassessmentofironstatusanderythropoiesis AT escanerojesusf biomarkersofhypochromiathecontemporaryassessmentofironstatusanderythropoiesis |