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Validation of New Allele-Specific Real-Time PCR System for Thiopurine Methyltransferase Genotyping in Korean Population

Introduction. Thiopurine drugs are metabolized via S-methylation and catalyzed by thiopurine S-methyltransferase (TPMT). Patients with very low TPMT activity are at high risk of fatal bone marrow toxicity when standard doses of thiopurine drugs are administered. TPMT genotyping can predict TPMT acti...

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Detalles Bibliográficos
Autores principales:	Kim, Sollip, Lee, Hye Won, Lee, Woochang, Chun, Sail, Min, Won-Ki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600258/ https://www.ncbi.nlm.nih.gov/pubmed/23555080 http://dx.doi.org/10.1155/2013/305704

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