Cargando…

PPAR Activation Induces M1 Macrophage Polarization via cPLA(2)-COX-2 Inhibition, Activating ROS Production against Leishmania mexicana

Defence against Leishmania depends upon Th1 inflammatory response and, a major problem in susceptible models, is the turnoff of the leishmanicidal activity of macrophages with IL-10, IL-4, and COX-2 upregulation, as well as immunosuppressive PGE(2), all together inhibiting the respiratory burst. Per...

Descripción completa

Detalles Bibliográficos
Autores principales:	Díaz-Gandarilla, J. A., Osorio-Trujillo, C., Hernández-Ramírez, V. I., Talamás-Rohana, P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600276/ https://www.ncbi.nlm.nih.gov/pubmed/23555077 http://dx.doi.org/10.1155/2013/215283

Ejemplares similares

Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia
por: Chang, Jia-Feng, et al.
Publicado: (2019)

Long-Term Lithium Treatment Increases cPLA(2) and iPLA(2) Activity in Cultured Cortical and Hippocampal Neurons
por: De-Paula, Vanessa de Jesus, et al.
Publicado: (2015)

Cyclin-Dependent Kinase 5 Regulates cPLA2 Activity and Neuroinflammation in Parkinson’s Disease
por: Paul, Sangita, et al.
Publicado: (2022)

Novel role of cPLA(2)α in membrane and actin dynamics
por: Moes, Maarten, et al.
Publicado: (2010)

cPLA(2)α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation
por: Ashcroft, Felicity J., et al.
Publicado: (2020)

Involvement of the γ Isoform of cPLA(2) in the Biosynthesis of Bioactive N-Acylethanolamines
por: Guo, Yiman, et al.
Publicado: (2021)

Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2α and COX-2 Expression
por: Hsu, Pei-Sung, et al.
Publicado: (2019)

Role of Prednisolone in Platelet Activation by Inhibiting TxA(2) Generation through the Regulation of cPLA(2) Phosphorylation
por: Kim, Sanggu, et al.
Publicado: (2023)

cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury
por: Li, Yun, et al.
Publicado: (2019)

Sarcophine-Diol Inhibits Expression of COX-2, Inhibits Activity of cPLA(2), Enhances Degradation of PLA(2) and PLC(γ)1 and Inhibits Cell Membrane Permeability in Mouse Melanoma B(16)F(10) Cells
por: Szymanski, Pawel T., et al.
Publicado: (2012)

Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-α-activated COX-2-cPLA2-PGE(2) Pathway
por: Tsai, Ming-Ming, et al.
Publicado: (2021)

Targeting cPLA(2) derived lipid hydroperoxides as a potential intervention for sarcopenia
por: Pharaoh, Gavin, et al.
Publicado: (2020)

Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFα Gene Expression in Macrophages via a cPLA(2)α/COX-1 Pathway
por: Astudillo, Alma M., et al.
Publicado: (2021)

Structure Activity Relationship and Molecular Docking of Some Quinazolines Bearing Sulfamerazine Moiety as New 3CLpro, cPLA2, sPLA2 Inhibitors
por: Hussein, Mohammed Abdalla, et al.
Publicado: (2023)

Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A(2) (GIVA cPLA(2))
por: Psarra, Anastasia, et al.
Publicado: (2018)

The effects of myelin on macrophage activation are phenotypic specific via cPLA(2) in the context of spinal cord injury inflammation
por: Kopper, Timothy J., et al.
Publicado: (2021)

Antiplatelet Effect of Daphnetin Is Regulated by cPLA(2)-Mediated Thromboxane A(2) Generation in Mice
por: Chaudhary, Preeti Kumari, et al.
Publicado: (2023)

Correction to “Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A(2) (GIVA cPLA(2))”
por: Psarra, Anastasia, et al.
Publicado: (2019)

Leptin Promotes cPLA(2) Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade
por: Hsu, Pei-Sung, et al.
Publicado: (2015)

LRP1 Controls cPLA(2) Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export
por: Zhou, Li, et al.
Publicado: (2009)

Interleukin 15 Primes Natural Killer Cells to Kill via NKG2D and cPLA2 and This Pathway Is Active in Psoriatic Arthritis
por: Tang, Fangming, et al.
Publicado: (2013)

PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma
por: Sarkar, Chinmoy, et al.
Publicado: (2019)

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
por: Gynther, Mikko, et al.
Publicado: (2022)

Dapagliflozin Reduces Apoptosis of Diabetic Retina and Human Retinal Microvascular Endothelial Cells Through ERK1/2/cPLA2/AA/ROS Pathway Independent of Hypoglycemic
por: Hu, Yuxin, et al.
Publicado: (2022)

Inhibition of Cytosolic Phospholipase A(2)α (cPLA(2)α) by Medicinal Plants in Relation to Their Phenolic Content
por: Arnold, Eva, et al.
Publicado: (2015)

Epidural Dexamethasone Decreased Inflammatory Hyperalgesia and Spinal cPLA(2) Expression in a Rat Formalin Test
por: Min, Sam-Hong, et al.
Publicado: (2014)

Lipopolysaccharide promoted proliferation and adipogenesis of preadipocytes through JAK/STAT and AMPK-regulated cPLA2 expression
por: Chang, Chao-Chien, et al.
Publicado: (2019)

Detection and Differentiation of Breast Cancer Sub-Types using a cPLA2α Activatable Fluorophore
por: Chiorazzo, Michael G., et al.
Publicado: (2019)

Inhibition of sPLA(2)-IIA Prevents LPS-Induced Neuroinflammation by Suppressing ERK1/2-cPLA(2)α Pathway in Mice Cerebral Cortex
por: Xiang, Yanxiao, et al.
Publicado: (2013)

Gigantol ameliorates CCl(4)-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway
por: Xue, Yaru, et al.
Publicado: (2020)

Phosphorylation of cPLA(2)α at Ser(505) Is Necessary for Its Translocation to PtdInsP(2)-Enriched Membranes
por: Casas, Javier, et al.
Publicado: (2022)

Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis
por: Xin, Chunxia, et al.
Publicado: (2019)

Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA(2) phosphorylation and translocation
por: Evans, John H, et al.
Publicado: (2002)

cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment
por: Mishra, Sanjay, et al.
Publicado: (2022)

Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization
por: Zhang, Haojie, et al.
Publicado: (2023)

cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes
por: Cai, Bishuang, et al.
Publicado: (2012)

Thrombin induces ferroptosis in triple-negative breast cancer through the cPLA2α/ACSL4 signaling pathway
por: Xu, Shuo, et al.
Publicado: (2023)

HDAC5 Loss Enhances Phospholipid-Derived Arachidonic Acid Generation and Confers Sensitivity to cPLA2 Inhibition in Pancreatic Cancer
por: Pan, Penglin, et al.
Publicado: (2022)

Dual role of the p38 MAPK/cPLA(2) pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists
por: Rukoyatkina, N, et al.
Publicado: (2013)

Cytosolic phospholipase A(2) (cPLA(2)) IVA as a potential signature molecule in cigarette smoke condensate induced pathologies in alveolar epithelial lineages
por: Yadav, Subodh K., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_p6af3vcjstebi4hane8g341p98