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Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population

Introduction. Idiopathic inflammatory myopathies (IIMs) are a group of chronic systemic autoimmune diseases that mainly affect the skeletal muscle. The common subtypes include adult dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). Most of the earlier studies that described...

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Autores principales: Ungprasert, Patompong, Leeaphorn, Napat, Hosiriluck, Nattamol, Chaiwatcharayut, Wikrom, Ammannagari, Nischala, Raddatz, Donald A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600325/
https://www.ncbi.nlm.nih.gov/pubmed/23533803
http://dx.doi.org/10.1155/2013/509354
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author Ungprasert, Patompong
Leeaphorn, Napat
Hosiriluck, Nattamol
Chaiwatcharayut, Wikrom
Ammannagari, Nischala
Raddatz, Donald A.
author_facet Ungprasert, Patompong
Leeaphorn, Napat
Hosiriluck, Nattamol
Chaiwatcharayut, Wikrom
Ammannagari, Nischala
Raddatz, Donald A.
author_sort Ungprasert, Patompong
collection PubMed
description Introduction. Idiopathic inflammatory myopathies (IIMs) are a group of chronic systemic autoimmune diseases that mainly affect the skeletal muscle. The common subtypes include adult dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). Most of the earlier studies that described the clinical characteristics of IIM as well as their association with cancer were conducted in Western population. Our study is the first systematic review that summarizes the clinical data of DM/PM in Asian population. Methods. We identified 14 case series of DM/PM that met our eligibility criteria. We then compared this data with that from previous reports from Europe and North America. Results. Our systematic review included 2518 patients. Dermatomyositis is more common, with the ratio of dermatomyositis to polymyositis being 1.36 : 1. 69% of them were females with mean age of 45.5 years. Extramuscular manifestations, including arthritis/arthralgia, dysphagia, and interstitial lung disease, are found in one-third of the patients. Malignancy was found in 10% of patients, with lung and nasopharyngeal carcinomas being the most common malignancies associated with these myopathies. Conclusion. Clinical presentation of PM/DM appears to be similar in both Western and Asian populations. However, the type of associated malignancies in Asians differs from that in Caucasians. Ethnic background should be one of the factors that clinicians should consider while screening for malignancy.
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spelling pubmed-36003252013-03-26 Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population Ungprasert, Patompong Leeaphorn, Napat Hosiriluck, Nattamol Chaiwatcharayut, Wikrom Ammannagari, Nischala Raddatz, Donald A. ISRN Rheumatol Review Article Introduction. Idiopathic inflammatory myopathies (IIMs) are a group of chronic systemic autoimmune diseases that mainly affect the skeletal muscle. The common subtypes include adult dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). Most of the earlier studies that described the clinical characteristics of IIM as well as their association with cancer were conducted in Western population. Our study is the first systematic review that summarizes the clinical data of DM/PM in Asian population. Methods. We identified 14 case series of DM/PM that met our eligibility criteria. We then compared this data with that from previous reports from Europe and North America. Results. Our systematic review included 2518 patients. Dermatomyositis is more common, with the ratio of dermatomyositis to polymyositis being 1.36 : 1. 69% of them were females with mean age of 45.5 years. Extramuscular manifestations, including arthritis/arthralgia, dysphagia, and interstitial lung disease, are found in one-third of the patients. Malignancy was found in 10% of patients, with lung and nasopharyngeal carcinomas being the most common malignancies associated with these myopathies. Conclusion. Clinical presentation of PM/DM appears to be similar in both Western and Asian populations. However, the type of associated malignancies in Asians differs from that in Caucasians. Ethnic background should be one of the factors that clinicians should consider while screening for malignancy. Hindawi Publishing Corporation 2013-02-25 /pmc/articles/PMC3600325/ /pubmed/23533803 http://dx.doi.org/10.1155/2013/509354 Text en Copyright © 2013 Patompong Ungprasert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ungprasert, Patompong
Leeaphorn, Napat
Hosiriluck, Nattamol
Chaiwatcharayut, Wikrom
Ammannagari, Nischala
Raddatz, Donald A.
Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population
title Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population
title_full Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population
title_fullStr Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population
title_full_unstemmed Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population
title_short Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population
title_sort clinical features of inflammatory myopathies and their association with malignancy: a systematic review in asian population
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600325/
https://www.ncbi.nlm.nih.gov/pubmed/23533803
http://dx.doi.org/10.1155/2013/509354
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