Cargando…

Nonlinear Population Pharmacokinetics of Sirolimus in Patients With Advanced Cancer

Sirolimus, the prototypical inhibitor of the mammalian target of rapamycin, has substantial antitumor activity. In this study, sirolimus showed nonlinear pharmacokinetic characteristics over a wide dose range (from 1 to 60 mg/week). The objective of this study was to develop a population pharmacokin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, K, Cohen, E E W, House, L K, Ramírez, J, Zhang, W, Ratain, M J, Bies, R R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600722/ https://www.ncbi.nlm.nih.gov/pubmed/23887441 http://dx.doi.org/10.1038/psp.2012.18

Ejemplares similares

The Effect of Tanreqing Injection on the Pharmacokinetics of Sirolimus in Rats
por: Zhang, Feng, et al.
Publicado: (2019)

Population pharmacokinetics of sirolimus in pediatric patients with kaposiform hemangioendothelioma: A retrospective study
por: Wang, Dongdong, et al.
Publicado: (2019)

Effects of a ritonavir‐containing regimen on the pharmacokinetics of sirolimus or everolimus in healthy adult subjects
por: Zha, Jiuhong, et al.
Publicado: (2022)

The first study in pediatric: Population pharmacokinetics of sirolimus and its application in Chinese children with immune cytopenia
por: Cheng, Xiaoling, et al.
Publicado: (2020)

Initial dose recommendation for sirolimus in paediatric kaposiform haemangioendothelioma patients based on population pharmacokinetics and pharmacogenomics
por: Chen, Xiao, et al.
Publicado: (2020)

Exploring Sirolimus Pharmacokinetic Variability Using Data Available from the Routine Clinical Care of Renal Transplant Patients – Population Pharmacokinetic Approach
por: Golubović, Bojana, et al.
Publicado: (2019)

Sirolimus-Associated Pruritus: Case Report and Review
por: Cheng, Joyce Y, et al.
Publicado: (2017)

Population pharmacokinetic modeling of intramuscular and oral dexamethasone and betamethasone in Indian women
por: Krzyzanski, Wojciech, et al.
Publicado: (2021)

Effect of sirolimus on insulin dynamics in horses
por: de Tonnerre, Demia J., et al.
Publicado: (2023)

Sirolimus Pharmacokinetics Variability Points to the Relevance of Therapeutic Drug Monitoring in Pediatric Oncology
por: Sabo, Amelia-Naomi, et al.
Publicado: (2021)

Sorafenib Dose Escalation is Not Uniformly Associated with Blood Pressure Elevations in Normotensive Patients with Advanced Malignancies
por: Karovic, Sanja, et al.
Publicado: (2014)

Integration of Physiologically-Based Pharmacokinetic Modeling into Early Clinical Development: An Investigation of the Pharmacokinetic Nonlinearity
por: Zhou, L, et al.
Publicado: (2015)

A phase I dose-escalation study to evaluate safety and tolerability of sorafenib combined with sirolimus in patients with advanced solid cancer
por: Desar, I M E, et al.
Publicado: (2010)

Population pharmacokinetics of clonazepam in saliva and plasma: Steps towards noninvasive pharmacokinetic studies in vulnerable populations
por: Kruizinga, Matthijs D., et al.
Publicado: (2021)

Population Pharmacokinetic and Pharmacodynamic Modeling of LY2510924 in Patients With Advanced Cancer
por: Bihorel, S, et al.
Publicado: (2017)

Predicting the Onset of Nonlinear Pharmacokinetics
por: Stein, Andrew M., et al.
Publicado: (2018)

Gorham-Stout disease: remission with sirolimus therapy
por: Yip, Stefanie W. Y., et al.
Publicado: (2023)

Physiologically‐based pharmacokinetic model of vaginally administered dapivirine ring and film formulations
por: Kay, Katherine, et al.
Publicado: (2018)

Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex
por: Chen, Xiao, et al.
Publicado: (2021)

Introduction to Population Pharmacokinetic/Pharmacodynamic Analysis With Nonlinear Mixed Effects Models
por: Graaf, P H van der
Publicado: (2014)

Sirolimus-induced pneumonitis
por: Singh, U., et al.
Publicado: (2009)

Lymphedema attributed to sirolimus
por: Ardalan, Mohammad-Reza
Publicado: (2013)

Sirolimus as frontline therapy for PTEN-mutated histiocytic sarcoma
por: Chohan, Karan L., et al.
Publicado: (2022)

Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors
por: Aregbe, Abdulateef O., et al.
Publicado: (2012)

Sirolimus treatment of severe congenital hyperinsulinism
por: Amato, Lisa A, et al.
Publicado: (2015)

Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate
por: Cabrera, Trevor B., et al.
Publicado: (2020)

Population pharmacokinetic characteristics of cemiplimab in patients with advanced malignancies
por: Yang, Feng, et al.
Publicado: (2021)

Nonlinear Population Pharmacokinetics of Anifrolumab in Healthy Volunteers and Patients With Systemic Lupus Erythematosus
por: Almquist, Joachim, et al.
Publicado: (2022)

Estimation of renal cell carcinoma treatment effects from disease progression modeling
por: Maitland, Michael L., et al.
Publicado: (2012)

Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants
por: Emoto, C, et al.
Publicado: (2015)

CYP3A5 and ABCB1 genotype influence tacrolimus and sirolimus pharmacokinetics in renal transplant recipients
por: Li, Yi, et al.
Publicado: (2015)

Sirolimus in the treatment of kaposiform lymphangiomatosis
por: Zhou, Jiangyuan, et al.
Publicado: (2021)

Unexpected sirolimus-stimulated airway hyperreactivity in lymphangioleiomyomatosis
por: Steagall, Wendy K., et al.
Publicado: (2023)

Sirolimus Induced Toxic Optic Neuropathy
por: Pakravan, Parastou, et al.
Publicado: (2023)

A population pharmacokinetic model for R- and S-citalopram and desmethylcitalopram in Alzheimer’s disease patients with agitation
por: Akil, Ayman, et al.
Publicado: (2015)

Sirolimus for patients with progressive epithelioid hemangioendothelioma
por: Smrke, Alannah M., et al.
Publicado: (2020)

Population Pharmacokinetic Modeling of Lucitanib in Patients with Advanced Cancer
por: Liao, Mingxiang, et al.
Publicado: (2022)

Sirolimus suppresses circulating fibrocytes in idiopathic pulmonary fibrosis in a randomized controlled crossover trial
por: Gomez-Manjarres, Diana C., et al.
Publicado: (2023)

Utility of sirolimus coated balloons in the peripheral vasculature – a review of the current literature
por: Linn, Y. L., et al.
Publicado: (2022)

Estimating parameters of nonlinear dynamic systems in pharmacology using chaos synchronization and grid search
por: Pillai, Nikhil, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_r1vo99a896o4b4818b8jqm5ahr