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A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development

Assessing the safety of pharmacotherapies is a primary goal of clinical trials in drug development. The low frequency of relevant side effects, however, often poses a significant challenge for risk assessment. Methodologies allowing robust extrapolation of safety statistics based on preclinical data...

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Detalles Bibliográficos
Autores principales:	Lippert, J, Brosch, M, von Kampen, O, Meyer, M, Siegmund, H.-U, Schafmayer, C, Becker, T, Laffert, B, Görlitz, L, Schreiber, S, Neuvonen, P J, Niemi, M, Hampe, J, Kuepfer, L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600730/ https://www.ncbi.nlm.nih.gov/pubmed/23835795 http://dx.doi.org/10.1038/psp.2012.14

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