Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

Antibodies targeting citrullinated proteins (ACPAs [anticitrullinated protein antibodies]) are commonly found in patients with rheumatoid arthritis (RA), strongly associate with distinct HLA-DR alleles, and predict a more aggressive disease course as compared with seronegative patients. Still, many...

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Detalles Bibliográficos
Autores principales: Amara, Khaled, Steen, Johanna, Murray, Fiona, Morbach, Henner, Fernandez-Rodriguez, Blanca M., Joshua, Vijay, Engström, Marianne, Snir, Omri, Israelsson, Lena, Catrina, Anca I., Wardemann, Hedda, Corti, Davide, Meffre, Eric, Klareskog, Lars, Malmström, Vivianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600900/
https://www.ncbi.nlm.nih.gov/pubmed/23440041
http://dx.doi.org/10.1084/jem.20121486

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