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Germinal center B cells govern their own fate via antibody feedback
Affinity maturation of B cells in germinal centers (GCs) is a process of evolution, involving random mutation of immunoglobulin genes followed by natural selection by T cells. Only B cells that have acquired antigen are able to interact with T cells. Antigen acquisition is dependent on the interacti...
Autores principales: | Zhang, Yang, Meyer-Hermann, Michael, George, Laura A., Figge, Marc Thilo, Khan, Mahmood, Goodall, Margaret, Young, Stephen P., Reynolds, Adam, Falciani, Francesco, Waisman, Ari, Notley, Clare A., Ehrenstein, Michael R., Kosco-Vilbois, Marie, Toellner, Kai-Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600904/ https://www.ncbi.nlm.nih.gov/pubmed/23420879 http://dx.doi.org/10.1084/jem.20120150 |
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