Myeloablative Temozolomide Enhances CD8(+) T-Cell Responses to Vaccine and Is Required for Efficacy against Brain Tumors in Mice

Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with high grade glioma and is routinely used to treat melanoma brain metastases. A prominent side effect of TMZ is induction of profound lymphopenia, which some suggest may be incompatible with immunotherapy. Conversely,...

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Detalles Bibliográficos
Autores principales: Sanchez-Perez, Luis A., Choi, Bryan D., Archer, Gary E., Cui, Xiuyu, Flores, Catherine, Johnson, Laura A., Schmittling, Robert J., Snyder, David, Herndon, James E., Bigner, Darell D., Mitchell, Duane A., Sampson, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601076/
https://www.ncbi.nlm.nih.gov/pubmed/23527092
http://dx.doi.org/10.1371/journal.pone.0059082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601076/
https://www.ncbi.nlm.nih.gov/pubmed/23527092
http://dx.doi.org/10.1371/journal.pone.0059082

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