Increased Cardiac Myocyte PDE5 Levels in Human and Murine Pressure Overload Hypertrophy Contribute to Adverse LV Remodeling

BACKGROUND: The intracellular second messenger cGMP protects the heart under pathological conditions. We examined expression of phosphodiesterase 5 (PDE5), an enzyme that hydrolyzes cGMP, in human and mouse hearts subjected to sustained left ventricular (LV) pressure overload. We also determined the...

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Detalles Bibliográficos
Autores principales: Vandenwijngaert, Sara, Pokreisz, Peter, Hermans, Hadewich, Gillijns, Hilde, Pellens, Marijke, Bax, Noortje A. M., Coppiello, Giulia, Oosterlinck, Wouter, Balogh, Agnes, Papp, Zoltan, Bouten, Carlijn V. C., Bartunek, Jozef, D'hooge, Jan, Luttun, Aernout, Verbeken, Erik, Herregods, Marie Christine, Herijgers, Paul, Bloch, Kenneth D., Janssens, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601083/
https://www.ncbi.nlm.nih.gov/pubmed/23527037
http://dx.doi.org/10.1371/journal.pone.0058841

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