Uncovering the mechanisms that regulate tumor-induced T-cell anergy

Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immun...

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Detalles Bibliográficos
Autores principales: Abe, Brian T., Macian, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601153/
https://www.ncbi.nlm.nih.gov/pubmed/23524444
http://dx.doi.org/10.4161/onci.22679
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author Abe, Brian T.
Macian, Fernando
author_facet Abe, Brian T.
Macian, Fernando
author_sort Abe, Brian T.
collection PubMed
description Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy.
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spelling pubmed-36011532013-03-22 Uncovering the mechanisms that regulate tumor-induced T-cell anergy Abe, Brian T. Macian, Fernando Oncoimmunology Author's View Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy. Landes Bioscience 2013-02-01 /pmc/articles/PMC3601153/ /pubmed/23524444 http://dx.doi.org/10.4161/onci.22679 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Abe, Brian T.
Macian, Fernando
Uncovering the mechanisms that regulate tumor-induced T-cell anergy
title Uncovering the mechanisms that regulate tumor-induced T-cell anergy
title_full Uncovering the mechanisms that regulate tumor-induced T-cell anergy
title_fullStr Uncovering the mechanisms that regulate tumor-induced T-cell anergy
title_full_unstemmed Uncovering the mechanisms that regulate tumor-induced T-cell anergy
title_short Uncovering the mechanisms that regulate tumor-induced T-cell anergy
title_sort uncovering the mechanisms that regulate tumor-induced t-cell anergy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601153/
https://www.ncbi.nlm.nih.gov/pubmed/23524444
http://dx.doi.org/10.4161/onci.22679
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AT macianfernando uncoveringthemechanismsthatregulatetumorinducedtcellanergy

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