Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression

Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer...

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Detalles Bibliográficos
Autores principales: Demers, Mélanie, Wagner, Denisa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601165/
https://www.ncbi.nlm.nih.gov/pubmed/23526174
http://dx.doi.org/10.4161/onci.22946
Descripción
Sumario:Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.

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