Role of c-MYC in tumor-associated macrophages and cancer progression

Transcription factors of the MYC family regulate several homeostatic cell functions, and their role as proto-oncogenes has been the focus of interest for decades. We have recently demonstrated that c-MYC is expressed by tumor-associated macrophages (TAMs) and regulates their phenotype and pro-tumor...

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Detalles Bibliográficos
Autores principales: Pello, Oscar M., Andrés, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601167/
https://www.ncbi.nlm.nih.gov/pubmed/23526468
http://dx.doi.org/10.4161/onci.22984
Descripción
Sumario:Transcription factors of the MYC family regulate several homeostatic cell functions, and their role as proto-oncogenes has been the focus of interest for decades. We have recently demonstrated that c-MYC is expressed by tumor-associated macrophages (TAMs) and regulates their phenotype and pro-tumor activities in vivo.

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