Retinoic acid on stage in antitumor immunity

The morphogenic role of retinoic acid (RA) in regulating immunity is underscored by our recent studies that show increased regional concentrations of RA and commensurate RA signaling in CD8(+) T cells within the tumor microenvironment. This study demonstrated for the first time that intrinsic RA sig...

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Detalles Bibliográficos
Autores principales: Guo, Yanxia, Nolle, Randolph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601168/
https://www.ncbi.nlm.nih.gov/pubmed/23526574
http://dx.doi.org/10.4161/onci.22985
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author Guo, Yanxia
Nolle, Randolph J.
author_facet Guo, Yanxia
Nolle, Randolph J.
author_sort Guo, Yanxia
collection PubMed
description The morphogenic role of retinoic acid (RA) in regulating immunity is underscored by our recent studies that show increased regional concentrations of RA and commensurate RA signaling in CD8(+) T cells within the tumor microenvironment. This study demonstrated for the first time that intrinsic RA signaling is required for tumor associated antigen (TAA)-specific CD8(+) T-cell survival and hence for tumor surveillance.
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spelling pubmed-36011682013-03-22 Retinoic acid on stage in antitumor immunity Guo, Yanxia Nolle, Randolph J. Oncoimmunology Author's View The morphogenic role of retinoic acid (RA) in regulating immunity is underscored by our recent studies that show increased regional concentrations of RA and commensurate RA signaling in CD8(+) T cells within the tumor microenvironment. This study demonstrated for the first time that intrinsic RA signaling is required for tumor associated antigen (TAA)-specific CD8(+) T-cell survival and hence for tumor surveillance. Landes Bioscience 2013-02-01 /pmc/articles/PMC3601168/ /pubmed/23526574 http://dx.doi.org/10.4161/onci.22985 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Guo, Yanxia
Nolle, Randolph J.
Retinoic acid on stage in antitumor immunity
title Retinoic acid on stage in antitumor immunity
title_full Retinoic acid on stage in antitumor immunity
title_fullStr Retinoic acid on stage in antitumor immunity
title_full_unstemmed Retinoic acid on stage in antitumor immunity
title_short Retinoic acid on stage in antitumor immunity
title_sort retinoic acid on stage in antitumor immunity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601168/
https://www.ncbi.nlm.nih.gov/pubmed/23526574
http://dx.doi.org/10.4161/onci.22985
work_keys_str_mv AT guoyanxia retinoicacidonstageinantitumorimmunity
AT nollerandolphj retinoicacidonstageinantitumorimmunity

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