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Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila
Complex organ shapes arise from the coordinate actions of individual cells. The Drosophila egg chamber is an organ-like structure that lengthens along its anterior–posterior axis as it grows. This morphogenesis depends on an unusual form of planar polarity in the organ’s outer epithelial layer, the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601364/ https://www.ncbi.nlm.nih.gov/pubmed/23509067 http://dx.doi.org/10.1083/jcb.201209129 |
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author | Lewellyn, Lindsay Cetera, Maureen Horne-Badovinac, Sally |
author_facet | Lewellyn, Lindsay Cetera, Maureen Horne-Badovinac, Sally |
author_sort | Lewellyn, Lindsay |
collection | PubMed |
description | Complex organ shapes arise from the coordinate actions of individual cells. The Drosophila egg chamber is an organ-like structure that lengthens along its anterior–posterior axis as it grows. This morphogenesis depends on an unusual form of planar polarity in the organ’s outer epithelial layer, the follicle cells. Interestingly, this epithelium also undergoes a directed migration that causes the egg chamber to rotate around its anterior–posterior axis. However, the functional relationship between planar polarity and migration in this tissue is unknown. We have previously reported that mutations in the Misshapen kinase disrupt follicle cell planar polarity. Here we show that Misshapen’s primary role in this system is to promote individual cell motility. Misshapen decreases integrin levels at the basal surface, which may facilitate detachment of each cell’s trailing edge. These data provide mechanistic insight into Misshapen’s conserved role in cell migration and suggest that follicle cell planar polarity may be an emergent property of individual cell migratory behaviors within the epithelium. |
format | Online Article Text |
id | pubmed-3601364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36013642013-09-18 Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila Lewellyn, Lindsay Cetera, Maureen Horne-Badovinac, Sally J Cell Biol Research Articles Complex organ shapes arise from the coordinate actions of individual cells. The Drosophila egg chamber is an organ-like structure that lengthens along its anterior–posterior axis as it grows. This morphogenesis depends on an unusual form of planar polarity in the organ’s outer epithelial layer, the follicle cells. Interestingly, this epithelium also undergoes a directed migration that causes the egg chamber to rotate around its anterior–posterior axis. However, the functional relationship between planar polarity and migration in this tissue is unknown. We have previously reported that mutations in the Misshapen kinase disrupt follicle cell planar polarity. Here we show that Misshapen’s primary role in this system is to promote individual cell motility. Misshapen decreases integrin levels at the basal surface, which may facilitate detachment of each cell’s trailing edge. These data provide mechanistic insight into Misshapen’s conserved role in cell migration and suggest that follicle cell planar polarity may be an emergent property of individual cell migratory behaviors within the epithelium. The Rockefeller University Press 2013-03-18 /pmc/articles/PMC3601364/ /pubmed/23509067 http://dx.doi.org/10.1083/jcb.201209129 Text en © 2013 Lewellyn et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Research Articles Lewellyn, Lindsay Cetera, Maureen Horne-Badovinac, Sally Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila |
title | Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila |
title_full | Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila |
title_fullStr | Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila |
title_full_unstemmed | Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila |
title_short | Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila |
title_sort | misshapen decreases integrin levels to promote epithelial motility and planar polarity in drosophila |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601364/ https://www.ncbi.nlm.nih.gov/pubmed/23509067 http://dx.doi.org/10.1083/jcb.201209129 |
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