Functional Impact of ABCB1 Variants on Interactions between P-Glycoprotein and Methadone

Methadone is a widely used substitution therapy for opioid addiction. Large inter-individual variability has been observed in methadone maintenance dosages and P-glycoprotein (P-gp) was considered to be one of the major contributors. To investigate the mechanism of P-gp’s interaction with methadone,...

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Detalles Bibliográficos
Autores principales: Hung, Chin-Chuan, Chiou, Mu-Han, Teng, Yu-Ning, Hsieh, Yow-Wen, Huang, Chieh-Liang, Lane, Hsien-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602015/
https://www.ncbi.nlm.nih.gov/pubmed/23527191
http://dx.doi.org/10.1371/journal.pone.0059419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602015/
https://www.ncbi.nlm.nih.gov/pubmed/23527191
http://dx.doi.org/10.1371/journal.pone.0059419

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