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Functional Impact of ABCB1 Variants on Interactions between P-Glycoprotein and Methadone
Methadone is a widely used substitution therapy for opioid addiction. Large inter-individual variability has been observed in methadone maintenance dosages and P-glycoprotein (P-gp) was considered to be one of the major contributors. To investigate the mechanism of P-gp’s interaction with methadone,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602015/ https://www.ncbi.nlm.nih.gov/pubmed/23527191 http://dx.doi.org/10.1371/journal.pone.0059419 |