Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix deposition

BACKGROUND: In this study we evaluated a novel approach to guide the bone marrow-driven articular cartilage repair response in skeletally aged rabbits. We hypothesized that dispersed chitosan particles implanted close to the bone marrow degrade in situ in a molecular mass-dependent manner, and attra...

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Detalles Bibliográficos
Autores principales: Lafantaisie-Favreau, Charles-Hubert, Guzmán-Morales, Jessica, Sun, Jun, Chen, Gaoping, Harris, Adam, Smith, Thomas D, Carli, Alberto, Henderson, Janet, Stanish, William D, Hoemann, Caroline D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602124/
https://www.ncbi.nlm.nih.gov/pubmed/23324433
http://dx.doi.org/10.1186/1471-2474-14-27

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