DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs

BACKGROUND: Double strand (ds) DNA breaks are a form of DNA damage that can be generated from both genotoxic exposures and physiologic processes, can disrupt cellular functions and can be lethal if not repaired properly. Physiologic dsDNA breaks are generated in a variety of normal cellular function...

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Detalles Bibliográficos
Autores principales: Innes, Cynthia L, Hesse, Jill E, Palii, Stela S, Helmink, Beth A, Holub, Abigail J, Sleckman, Barry P, Paules, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602184/
https://www.ncbi.nlm.nih.gov/pubmed/23496831
http://dx.doi.org/10.1186/1471-2164-14-163

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