A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected

Protein misfolding and aggregation in intracellular and extracellular spaces is regarded as a main marker of the presence of degenerative disorders such as amyloidoses. To elucidate the mechanisms of protein misfolding, the interaction of proteins with inorganic surfaces is of particular relevance,...

Descripción completa

Detalles Bibliográficos
Autores principales: Apicella, Alessandra, Soncini, Monica, Deriu, Marco Agostino, Natalello, Antonino, Bonanomi, Marcella, Dellasega, David, Tortora, Paolo, Regonesi, Maria Elena, Casari, Carlo Spartaco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602447/
https://www.ncbi.nlm.nih.gov/pubmed/23527026
http://dx.doi.org/10.1371/journal.pone.0058794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602447/
https://www.ncbi.nlm.nih.gov/pubmed/23527026
http://dx.doi.org/10.1371/journal.pone.0058794

Ejemplares similares