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Rab3D Is Critical for Secretory Granule Maturation in PC12 Cells

Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex. This maturation process is characterized by acidification-dependent processing of cargo...

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Detalles Bibliográficos
Autores principales: Kögel, Tanja, Rudolf, Rüdiger, Hodneland, Erlend, Copier, John, Regazzi, Romano, Tooze, Sharon A., Gerdes, Hans-Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602456/
https://www.ncbi.nlm.nih.gov/pubmed/23526941
http://dx.doi.org/10.1371/journal.pone.0057321