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Increased Collagen Synthesis Rate during Wound Healing in Muscle
Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602539/ https://www.ncbi.nlm.nih.gov/pubmed/23526975 http://dx.doi.org/10.1371/journal.pone.0058324 |
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author | Zhou, Shaobo Salisbury, Jonathan Preedy, Victor R. Emery, Peter W. |
author_facet | Zhou, Shaobo Salisbury, Jonathan Preedy, Victor R. Emery, Peter W. |
author_sort | Zhou, Shaobo |
collection | PubMed |
description | Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and 860% on days 2 and 7 respectively after surgery in the wounded muscle compared with an undamaged area of the same muscle. Collagen content was increased by approximately 100% at both day 2 and day 7. These results demonstrate that collagen deposition during wound healing in muscle is achieved entirely by an increase in the rate of collagen synthesis. |
format | Online Article Text |
id | pubmed-3602539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36025392013-03-22 Increased Collagen Synthesis Rate during Wound Healing in Muscle Zhou, Shaobo Salisbury, Jonathan Preedy, Victor R. Emery, Peter W. PLoS One Research Article Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and 860% on days 2 and 7 respectively after surgery in the wounded muscle compared with an undamaged area of the same muscle. Collagen content was increased by approximately 100% at both day 2 and day 7. These results demonstrate that collagen deposition during wound healing in muscle is achieved entirely by an increase in the rate of collagen synthesis. Public Library of Science 2013-03-19 /pmc/articles/PMC3602539/ /pubmed/23526975 http://dx.doi.org/10.1371/journal.pone.0058324 Text en © 2013 Zhou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhou, Shaobo Salisbury, Jonathan Preedy, Victor R. Emery, Peter W. Increased Collagen Synthesis Rate during Wound Healing in Muscle |
title | Increased Collagen Synthesis Rate during Wound Healing in Muscle |
title_full | Increased Collagen Synthesis Rate during Wound Healing in Muscle |
title_fullStr | Increased Collagen Synthesis Rate during Wound Healing in Muscle |
title_full_unstemmed | Increased Collagen Synthesis Rate during Wound Healing in Muscle |
title_short | Increased Collagen Synthesis Rate during Wound Healing in Muscle |
title_sort | increased collagen synthesis rate during wound healing in muscle |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602539/ https://www.ncbi.nlm.nih.gov/pubmed/23526975 http://dx.doi.org/10.1371/journal.pone.0058324 |
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