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Methylene blue as an early diagnostic marker for oral precancer and cancer
Oral cancer is one of the most common neoplasm’s and is ranked eighth in the cancer incidence worldwide. Early detection is of critical importance because survival rates markedly improve. In vivo staining is a simple, inexpensive, and fairly sensitive method. Involved 120 patients (50 with Premalign...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602613/ https://www.ncbi.nlm.nih.gov/pubmed/23524482 http://dx.doi.org/10.1186/2193-1801-2-95 |
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author | Riaz, Akhtar Shreedhar, Balasundari Kamboj, Mala Natarajan, S |
author_facet | Riaz, Akhtar Shreedhar, Balasundari Kamboj, Mala Natarajan, S |
author_sort | Riaz, Akhtar |
collection | PubMed |
description | Oral cancer is one of the most common neoplasm’s and is ranked eighth in the cancer incidence worldwide. Early detection is of critical importance because survival rates markedly improve. In vivo staining is a simple, inexpensive, and fairly sensitive method. Involved 120 patients (50 with Premalignant Lesion, 50 with OSCC and 20 controls) stained by Methylene Blue (MB). The results of MB uptake were compared with a simultaneous biopsy of these lesions. Pathologically confirmed precancers and cancers were the positive targets of this screening, while hyperkeratosis without dysplasia and no evidence of malignancy were sorted as negative subjects of screening. The results revealed sensitivity of 91.4%, specificity of 66.6%, positive predictive value 97.7% and negative predictive value 33% leading to diagnostic accuracy of MB stain to 90%. We state that MB staining is useful diagnostic tool in community oral cancer screening programmes for high-risk individuals. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2193-1801-2-95) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-3602613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-36026132013-03-20 Methylene blue as an early diagnostic marker for oral precancer and cancer Riaz, Akhtar Shreedhar, Balasundari Kamboj, Mala Natarajan, S Springerplus Research Oral cancer is one of the most common neoplasm’s and is ranked eighth in the cancer incidence worldwide. Early detection is of critical importance because survival rates markedly improve. In vivo staining is a simple, inexpensive, and fairly sensitive method. Involved 120 patients (50 with Premalignant Lesion, 50 with OSCC and 20 controls) stained by Methylene Blue (MB). The results of MB uptake were compared with a simultaneous biopsy of these lesions. Pathologically confirmed precancers and cancers were the positive targets of this screening, while hyperkeratosis without dysplasia and no evidence of malignancy were sorted as negative subjects of screening. The results revealed sensitivity of 91.4%, specificity of 66.6%, positive predictive value 97.7% and negative predictive value 33% leading to diagnostic accuracy of MB stain to 90%. We state that MB staining is useful diagnostic tool in community oral cancer screening programmes for high-risk individuals. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2193-1801-2-95) contains supplementary material, which is available to authorized users. Springer International Publishing 2013-03-09 /pmc/articles/PMC3602613/ /pubmed/23524482 http://dx.doi.org/10.1186/2193-1801-2-95 Text en © Riaz et al.; licensee Springer. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Riaz, Akhtar Shreedhar, Balasundari Kamboj, Mala Natarajan, S Methylene blue as an early diagnostic marker for oral precancer and cancer |
title | Methylene blue as an early diagnostic marker for oral precancer and cancer |
title_full | Methylene blue as an early diagnostic marker for oral precancer and cancer |
title_fullStr | Methylene blue as an early diagnostic marker for oral precancer and cancer |
title_full_unstemmed | Methylene blue as an early diagnostic marker for oral precancer and cancer |
title_short | Methylene blue as an early diagnostic marker for oral precancer and cancer |
title_sort | methylene blue as an early diagnostic marker for oral precancer and cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602613/ https://www.ncbi.nlm.nih.gov/pubmed/23524482 http://dx.doi.org/10.1186/2193-1801-2-95 |
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