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TIARA genome database: update 2013
The Total Integrated Archive of short-Read and Array (TIARA; http://tiara.gmi.ac.kr) database stores and integrates human genome data generated from multiple technologies including next-generation sequencing and high-resolution comparative genomic hybridization array. The TIARA genome browser is a p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602786/ https://www.ncbi.nlm.nih.gov/pubmed/23515433 http://dx.doi.org/10.1093/database/bat003 |
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author | Hong, Dongwan Lee, Jongkeun Bleazard, Thomas Jung, HyunChul Ju, Young Seok Yu, Saet-byeol Kim, Sujung Park, Sung-Soo Kim, Jong-Il Seo, Jeong-Sun |
author_facet | Hong, Dongwan Lee, Jongkeun Bleazard, Thomas Jung, HyunChul Ju, Young Seok Yu, Saet-byeol Kim, Sujung Park, Sung-Soo Kim, Jong-Il Seo, Jeong-Sun |
author_sort | Hong, Dongwan |
collection | PubMed |
description | The Total Integrated Archive of short-Read and Array (TIARA; http://tiara.gmi.ac.kr) database stores and integrates human genome data generated from multiple technologies including next-generation sequencing and high-resolution comparative genomic hybridization array. The TIARA genome browser is a powerful tool for the analysis of personal genomic information by exploring genomic variants such as SNPs, indels and structural variants simultaneously. As of September 2012, the TIARA database provides raw data and variant information for 13 sequenced whole genomes, 16 sequenced transcriptomes and 33 high resolution array assays. Sequencing reads are available at a depth of ∼30× for whole genomes and 50× for transcriptomes. Information on genomic variants includes a total of ∼9.56 million SNPs, 23 025 of which are non-synonymous SNPs, and ∼1.19 million indels. In this update, by adding high coverage sequencing of additional human individuals, the TIARA genome database now provides an extensive record of rare variants in humans. Following TIARA’s fundamentally integrative approach, new transcriptome sequencing data are matched with whole-genome sequencing data in the genome browser. Users can here observe, for example, the expression levels of human genes with allele-specific quantification. Improvements to the TIARA genome browser include the intuitive display of new complex and large-scale data sets. |
format | Online Article Text |
id | pubmed-3602786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36027862013-03-22 TIARA genome database: update 2013 Hong, Dongwan Lee, Jongkeun Bleazard, Thomas Jung, HyunChul Ju, Young Seok Yu, Saet-byeol Kim, Sujung Park, Sung-Soo Kim, Jong-Il Seo, Jeong-Sun Database (Oxford) Database Update The Total Integrated Archive of short-Read and Array (TIARA; http://tiara.gmi.ac.kr) database stores and integrates human genome data generated from multiple technologies including next-generation sequencing and high-resolution comparative genomic hybridization array. The TIARA genome browser is a powerful tool for the analysis of personal genomic information by exploring genomic variants such as SNPs, indels and structural variants simultaneously. As of September 2012, the TIARA database provides raw data and variant information for 13 sequenced whole genomes, 16 sequenced transcriptomes and 33 high resolution array assays. Sequencing reads are available at a depth of ∼30× for whole genomes and 50× for transcriptomes. Information on genomic variants includes a total of ∼9.56 million SNPs, 23 025 of which are non-synonymous SNPs, and ∼1.19 million indels. In this update, by adding high coverage sequencing of additional human individuals, the TIARA genome database now provides an extensive record of rare variants in humans. Following TIARA’s fundamentally integrative approach, new transcriptome sequencing data are matched with whole-genome sequencing data in the genome browser. Users can here observe, for example, the expression levels of human genes with allele-specific quantification. Improvements to the TIARA genome browser include the intuitive display of new complex and large-scale data sets. Oxford University Press 2013-03-19 /pmc/articles/PMC3602786/ /pubmed/23515433 http://dx.doi.org/10.1093/database/bat003 Text en © The Author(s) 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Update Hong, Dongwan Lee, Jongkeun Bleazard, Thomas Jung, HyunChul Ju, Young Seok Yu, Saet-byeol Kim, Sujung Park, Sung-Soo Kim, Jong-Il Seo, Jeong-Sun TIARA genome database: update 2013 |
title | TIARA genome database: update 2013 |
title_full | TIARA genome database: update 2013 |
title_fullStr | TIARA genome database: update 2013 |
title_full_unstemmed | TIARA genome database: update 2013 |
title_short | TIARA genome database: update 2013 |
title_sort | tiara genome database: update 2013 |
topic | Database Update |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602786/ https://www.ncbi.nlm.nih.gov/pubmed/23515433 http://dx.doi.org/10.1093/database/bat003 |
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