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High-density lipoprotein cholesterol: How High

The high-density lipoprotein cholesterol (HDL-C) is considered anti-atherogenic good cholesterol. It is involved in reverse transport of lipids. Epidemiological studies have found inverse relationship of HDL-C and coronary heart disease (CHD) risk. When grouped according to HDL-C, subjects having HD...

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Detalles Bibliográficos
Autores principales: Rajagopal, G., Suresh, V., Sachan, Alok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603035/
https://www.ncbi.nlm.nih.gov/pubmed/23565387
http://dx.doi.org/10.4103/2230-8210.104048
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author Rajagopal, G.
Suresh, V.
Sachan, Alok
author_facet Rajagopal, G.
Suresh, V.
Sachan, Alok
author_sort Rajagopal, G.
collection PubMed
description The high-density lipoprotein cholesterol (HDL-C) is considered anti-atherogenic good cholesterol. It is involved in reverse transport of lipids. Epidemiological studies have found inverse relationship of HDL-C and coronary heart disease (CHD) risk. When grouped according to HDL-C, subjects having HDL-C more than 60 mg/dL had lesser risk of CHD than those having HDL-C of 40-60 mg/dL, who in turn had lesser risk than those who had HDL-C less than 40 mg/dL. No upper limit for beneficial effect of HDL-C on CHD risk has been identified. The goals of treating patients with low HDL-C have not been firmly established. Though many drugs are known to improve HDL-C concentration, statins are proven to improve CHD risk and mortality. Cholesteryl ester transfer protein (CETP) is involved in metabolism of HDL-C and its inhibitors are actively being screened for clinical utility. However, final answer is still awaited on CETP-inhibitors.
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spelling pubmed-36030352013-04-05 High-density lipoprotein cholesterol: How High Rajagopal, G. Suresh, V. Sachan, Alok Indian J Endocrinol Metab Mini Review The high-density lipoprotein cholesterol (HDL-C) is considered anti-atherogenic good cholesterol. It is involved in reverse transport of lipids. Epidemiological studies have found inverse relationship of HDL-C and coronary heart disease (CHD) risk. When grouped according to HDL-C, subjects having HDL-C more than 60 mg/dL had lesser risk of CHD than those having HDL-C of 40-60 mg/dL, who in turn had lesser risk than those who had HDL-C less than 40 mg/dL. No upper limit for beneficial effect of HDL-C on CHD risk has been identified. The goals of treating patients with low HDL-C have not been firmly established. Though many drugs are known to improve HDL-C concentration, statins are proven to improve CHD risk and mortality. Cholesteryl ester transfer protein (CETP) is involved in metabolism of HDL-C and its inhibitors are actively being screened for clinical utility. However, final answer is still awaited on CETP-inhibitors. Medknow Publications & Media Pvt Ltd 2012-12 /pmc/articles/PMC3603035/ /pubmed/23565387 http://dx.doi.org/10.4103/2230-8210.104048 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini Review
Rajagopal, G.
Suresh, V.
Sachan, Alok
High-density lipoprotein cholesterol: How High
title High-density lipoprotein cholesterol: How High
title_full High-density lipoprotein cholesterol: How High
title_fullStr High-density lipoprotein cholesterol: How High
title_full_unstemmed High-density lipoprotein cholesterol: How High
title_short High-density lipoprotein cholesterol: How High
title_sort high-density lipoprotein cholesterol: how high
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603035/
https://www.ncbi.nlm.nih.gov/pubmed/23565387
http://dx.doi.org/10.4103/2230-8210.104048
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