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High-density lipoprotein cholesterol: How High
The high-density lipoprotein cholesterol (HDL-C) is considered anti-atherogenic good cholesterol. It is involved in reverse transport of lipids. Epidemiological studies have found inverse relationship of HDL-C and coronary heart disease (CHD) risk. When grouped according to HDL-C, subjects having HD...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603035/ https://www.ncbi.nlm.nih.gov/pubmed/23565387 http://dx.doi.org/10.4103/2230-8210.104048 |
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author | Rajagopal, G. Suresh, V. Sachan, Alok |
author_facet | Rajagopal, G. Suresh, V. Sachan, Alok |
author_sort | Rajagopal, G. |
collection | PubMed |
description | The high-density lipoprotein cholesterol (HDL-C) is considered anti-atherogenic good cholesterol. It is involved in reverse transport of lipids. Epidemiological studies have found inverse relationship of HDL-C and coronary heart disease (CHD) risk. When grouped according to HDL-C, subjects having HDL-C more than 60 mg/dL had lesser risk of CHD than those having HDL-C of 40-60 mg/dL, who in turn had lesser risk than those who had HDL-C less than 40 mg/dL. No upper limit for beneficial effect of HDL-C on CHD risk has been identified. The goals of treating patients with low HDL-C have not been firmly established. Though many drugs are known to improve HDL-C concentration, statins are proven to improve CHD risk and mortality. Cholesteryl ester transfer protein (CETP) is involved in metabolism of HDL-C and its inhibitors are actively being screened for clinical utility. However, final answer is still awaited on CETP-inhibitors. |
format | Online Article Text |
id | pubmed-3603035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36030352013-04-05 High-density lipoprotein cholesterol: How High Rajagopal, G. Suresh, V. Sachan, Alok Indian J Endocrinol Metab Mini Review The high-density lipoprotein cholesterol (HDL-C) is considered anti-atherogenic good cholesterol. It is involved in reverse transport of lipids. Epidemiological studies have found inverse relationship of HDL-C and coronary heart disease (CHD) risk. When grouped according to HDL-C, subjects having HDL-C more than 60 mg/dL had lesser risk of CHD than those having HDL-C of 40-60 mg/dL, who in turn had lesser risk than those who had HDL-C less than 40 mg/dL. No upper limit for beneficial effect of HDL-C on CHD risk has been identified. The goals of treating patients with low HDL-C have not been firmly established. Though many drugs are known to improve HDL-C concentration, statins are proven to improve CHD risk and mortality. Cholesteryl ester transfer protein (CETP) is involved in metabolism of HDL-C and its inhibitors are actively being screened for clinical utility. However, final answer is still awaited on CETP-inhibitors. Medknow Publications & Media Pvt Ltd 2012-12 /pmc/articles/PMC3603035/ /pubmed/23565387 http://dx.doi.org/10.4103/2230-8210.104048 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Mini Review Rajagopal, G. Suresh, V. Sachan, Alok High-density lipoprotein cholesterol: How High |
title | High-density lipoprotein cholesterol: How High |
title_full | High-density lipoprotein cholesterol: How High |
title_fullStr | High-density lipoprotein cholesterol: How High |
title_full_unstemmed | High-density lipoprotein cholesterol: How High |
title_short | High-density lipoprotein cholesterol: How High |
title_sort | high-density lipoprotein cholesterol: how high |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603035/ https://www.ncbi.nlm.nih.gov/pubmed/23565387 http://dx.doi.org/10.4103/2230-8210.104048 |
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