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Pituitary Gigantism: A Case Report
OBJECTIVE: To present a rare case of gigantism. CASE REPORT: A 25-year-old lady presented with increased statural growth and enlarged body parts noticed since the age of 14 years, primary amenorrhea, and frontal headache for the last 2 years. She has also been suffering from non-inflammatory low bac...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603049/ https://www.ncbi.nlm.nih.gov/pubmed/23565401 http://dx.doi.org/10.4103/2230-8210.104061 |
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author | Bhattacharjee, Rana Roy, Ajitesh Goswami, Soumik Selvan, Chitra Chakraborty, Partha P. Ghosh, Sujoy Biswas, Dibakar Dasgupta, Ranen Mukhopadhyay, Satinath Chowdhury, Subhankar |
author_facet | Bhattacharjee, Rana Roy, Ajitesh Goswami, Soumik Selvan, Chitra Chakraborty, Partha P. Ghosh, Sujoy Biswas, Dibakar Dasgupta, Ranen Mukhopadhyay, Satinath Chowdhury, Subhankar |
author_sort | Bhattacharjee, Rana |
collection | PubMed |
description | OBJECTIVE: To present a rare case of gigantism. CASE REPORT: A 25-year-old lady presented with increased statural growth and enlarged body parts noticed since the age of 14 years, primary amenorrhea, and frontal headache for the last 2 years. She has also been suffering from non-inflammatory low back pain with progressive kyphosis and pain in the knees, ankles, and elbows for the last 5 years. There was no history of visual disturbance, vomiting, galactorrhoea, cold intolerance. She had no siblings. Family history was non-contributory. Blood pressure was normal. Height 221 cm, weight 138 kg, body mass index (BMI)28. There was coarsening of facial features along with frontal bossing and prognathism, large hands and feet, and small goitre. Patient had severe kyphosis and osteoarthritis of knees. Confrontation perimetry suggested bitemporal hemianopia. Breast and pubic hair were of Tanner stage 1. Serum insulin like growth factor-1 (IGF1) was 703 ng/ml with all glucose suppressedgrowth hormone (GH)values of >40 ng/ml. Prolactin was 174 ng/ml. Basal serum Lutenising Hormone (LH), follicle stimulating Hormone (FSH) was low. Oral glucose tolerance test (OGTT), liver and renal function tests, basal cortisol and thyroid profile, Calcium, phosphorus and Intact Parathyroid hormone (iPTH) were normal. Computed tomographyscan of brain showed large pituitary macroadenoma. Automated perimetry confirmed bitemporal hemianopia. A diagnosis of gigantism due to GH secreting pituitary macroadenoma with hypogonadotrophichypogonadism was made. Debulking pituitary surgery followed by somatostatin analogue therapy with gonadal steroid replacement had been planned, but the patient refused further treatment. |
format | Online Article Text |
id | pubmed-3603049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36030492013-04-05 Pituitary Gigantism: A Case Report Bhattacharjee, Rana Roy, Ajitesh Goswami, Soumik Selvan, Chitra Chakraborty, Partha P. Ghosh, Sujoy Biswas, Dibakar Dasgupta, Ranen Mukhopadhyay, Satinath Chowdhury, Subhankar Indian J Endocrinol Metab Brief Communication OBJECTIVE: To present a rare case of gigantism. CASE REPORT: A 25-year-old lady presented with increased statural growth and enlarged body parts noticed since the age of 14 years, primary amenorrhea, and frontal headache for the last 2 years. She has also been suffering from non-inflammatory low back pain with progressive kyphosis and pain in the knees, ankles, and elbows for the last 5 years. There was no history of visual disturbance, vomiting, galactorrhoea, cold intolerance. She had no siblings. Family history was non-contributory. Blood pressure was normal. Height 221 cm, weight 138 kg, body mass index (BMI)28. There was coarsening of facial features along with frontal bossing and prognathism, large hands and feet, and small goitre. Patient had severe kyphosis and osteoarthritis of knees. Confrontation perimetry suggested bitemporal hemianopia. Breast and pubic hair were of Tanner stage 1. Serum insulin like growth factor-1 (IGF1) was 703 ng/ml with all glucose suppressedgrowth hormone (GH)values of >40 ng/ml. Prolactin was 174 ng/ml. Basal serum Lutenising Hormone (LH), follicle stimulating Hormone (FSH) was low. Oral glucose tolerance test (OGTT), liver and renal function tests, basal cortisol and thyroid profile, Calcium, phosphorus and Intact Parathyroid hormone (iPTH) were normal. Computed tomographyscan of brain showed large pituitary macroadenoma. Automated perimetry confirmed bitemporal hemianopia. A diagnosis of gigantism due to GH secreting pituitary macroadenoma with hypogonadotrophichypogonadism was made. Debulking pituitary surgery followed by somatostatin analogue therapy with gonadal steroid replacement had been planned, but the patient refused further treatment. Medknow Publications & Media Pvt Ltd 2012-12 /pmc/articles/PMC3603049/ /pubmed/23565401 http://dx.doi.org/10.4103/2230-8210.104061 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Bhattacharjee, Rana Roy, Ajitesh Goswami, Soumik Selvan, Chitra Chakraborty, Partha P. Ghosh, Sujoy Biswas, Dibakar Dasgupta, Ranen Mukhopadhyay, Satinath Chowdhury, Subhankar Pituitary Gigantism: A Case Report |
title | Pituitary Gigantism: A Case Report |
title_full | Pituitary Gigantism: A Case Report |
title_fullStr | Pituitary Gigantism: A Case Report |
title_full_unstemmed | Pituitary Gigantism: A Case Report |
title_short | Pituitary Gigantism: A Case Report |
title_sort | pituitary gigantism: a case report |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603049/ https://www.ncbi.nlm.nih.gov/pubmed/23565401 http://dx.doi.org/10.4103/2230-8210.104061 |
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