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Two cases of fetal goiter

INTRODUCTION: Anterior fetal neck masses are rarely encountered. Careful routine ultrasound screening can reveal intrauterine fetal goiters (FGs). The incidence of goitrous hypothyroidism is 1 in 30,000-50,000 live births. The consequences of both FG and impaired thyroid function are serious. AIMS A...

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Autores principales: Saini, Ashish, Reddy, Murli Manohar, Panchani, Roopal, Varma, Tarun, Gupta, Nitinranjan, Tripathi, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603076/
https://www.ncbi.nlm.nih.gov/pubmed/23565428
http://dx.doi.org/10.4103/2230-8210.104092
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author Saini, Ashish
Reddy, Murli Manohar
Panchani, Roopal
Varma, Tarun
Gupta, Nitinranjan
Tripathi, Sudhir
author_facet Saini, Ashish
Reddy, Murli Manohar
Panchani, Roopal
Varma, Tarun
Gupta, Nitinranjan
Tripathi, Sudhir
author_sort Saini, Ashish
collection PubMed
description INTRODUCTION: Anterior fetal neck masses are rarely encountered. Careful routine ultrasound screening can reveal intrauterine fetal goiters (FGs). The incidence of goitrous hypothyroidism is 1 in 30,000-50,000 live births. The consequences of both FG and impaired thyroid function are serious. AIMS AND OBJECTIVES: To emphasize role of ultrasound in both invasive and non-invasive management of FG. MATERIALS AND METHODS: Two pregnant patients, during second trimester, underwent routine antenatal ultrasound revealing FG, were investigated and managed. RESULTS: Case 1: Revealed FG with fetal hypothyroidism. Intra-amniotic injection l-thyroxine given. Follow-up ultrasound confirmed the reduction of the goiter size. At birth, thyroid dyshormogenesis was suspected and neonate discharged on 50 mcg levothyroxine/day with normal growth and development so far. Case 2: Hypothyroid mother with twin pregnancy revealed FG, in twin 1, confirmed on magnetic resonance imaging (1.5 × 1.63 cm). The other twin had no thyroid swelling. Cordocentesis confirmed hypothyroidism in twin 1. Maternal thyroxine dose increased as per biochemical parameters leading to reduction in FG size. Mother delivered preterm and none of the twins had thyroid swelling. Fetal euthyroidism was confirmed on biochemical screening. CONCLUSION: FG during pregnancy should be thoroughly evaluated, diagnosed and immediately treated; although in utero options for fetal hypothyroidism management are available, emphasis should be laid on non-invasive procedures. Newer and better resolution techniques in ultrasonography are more specific and at the same time are less harmful.
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spelling pubmed-36030762013-04-05 Two cases of fetal goiter Saini, Ashish Reddy, Murli Manohar Panchani, Roopal Varma, Tarun Gupta, Nitinranjan Tripathi, Sudhir Indian J Endocrinol Metab Brief Communication INTRODUCTION: Anterior fetal neck masses are rarely encountered. Careful routine ultrasound screening can reveal intrauterine fetal goiters (FGs). The incidence of goitrous hypothyroidism is 1 in 30,000-50,000 live births. The consequences of both FG and impaired thyroid function are serious. AIMS AND OBJECTIVES: To emphasize role of ultrasound in both invasive and non-invasive management of FG. MATERIALS AND METHODS: Two pregnant patients, during second trimester, underwent routine antenatal ultrasound revealing FG, were investigated and managed. RESULTS: Case 1: Revealed FG with fetal hypothyroidism. Intra-amniotic injection l-thyroxine given. Follow-up ultrasound confirmed the reduction of the goiter size. At birth, thyroid dyshormogenesis was suspected and neonate discharged on 50 mcg levothyroxine/day with normal growth and development so far. Case 2: Hypothyroid mother with twin pregnancy revealed FG, in twin 1, confirmed on magnetic resonance imaging (1.5 × 1.63 cm). The other twin had no thyroid swelling. Cordocentesis confirmed hypothyroidism in twin 1. Maternal thyroxine dose increased as per biochemical parameters leading to reduction in FG size. Mother delivered preterm and none of the twins had thyroid swelling. Fetal euthyroidism was confirmed on biochemical screening. CONCLUSION: FG during pregnancy should be thoroughly evaluated, diagnosed and immediately treated; although in utero options for fetal hypothyroidism management are available, emphasis should be laid on non-invasive procedures. Newer and better resolution techniques in ultrasonography are more specific and at the same time are less harmful. Medknow Publications & Media Pvt Ltd 2012-12 /pmc/articles/PMC3603076/ /pubmed/23565428 http://dx.doi.org/10.4103/2230-8210.104092 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Saini, Ashish
Reddy, Murli Manohar
Panchani, Roopal
Varma, Tarun
Gupta, Nitinranjan
Tripathi, Sudhir
Two cases of fetal goiter
title Two cases of fetal goiter
title_full Two cases of fetal goiter
title_fullStr Two cases of fetal goiter
title_full_unstemmed Two cases of fetal goiter
title_short Two cases of fetal goiter
title_sort two cases of fetal goiter
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603076/
https://www.ncbi.nlm.nih.gov/pubmed/23565428
http://dx.doi.org/10.4103/2230-8210.104092
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