De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

A small number of rare, recurrent genomic copy number variants (CNVs) are known to substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity in people with schizophrenia and other neurodevelopmental phenotypes to which these CNVs contribute, CNVs with large effect...

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Detalles Bibliográficos
Autores principales: Kirov, G, Pocklington, A J, Holmans, P, Ivanov, D, Ikeda, M, Ruderfer, D, Moran, J, Chambert, K, Toncheva, D, Georgieva, L, Grozeva, D, Fjodorova, M, Wollerton, R, Rees, E, Nikolov, I, van de Lagemaat, L N, Bayés, À, Fernandez, E, Olason, P I, Böttcher, Y, Komiyama, N H, Collins, M O, Choudhary, J, Stefansson, K, Stefansson, H, Grant, S G N, Purcell, S, Sklar, P, O'Donovan, M C, Owen, M J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603134/
https://www.ncbi.nlm.nih.gov/pubmed/22083728
http://dx.doi.org/10.1038/mp.2011.154

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