Cargando…

Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection

Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifie...

Descripción completa

Detalles Bibliográficos
Autores principales: Harvie, Marina, Camberis, Mali, Le Gros, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603274/
https://www.ncbi.nlm.nih.gov/pubmed/23518620
http://dx.doi.org/10.3389/fimmu.2013.00074
_version_ 1782263662263664640
author Harvie, Marina
Camberis, Mali
Le Gros, Graham
author_facet Harvie, Marina
Camberis, Mali
Le Gros, Graham
author_sort Harvie, Marina
collection PubMed
description Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salient features of parasitic worm infection, including parasite development through sequential larval stages as it migrates through specific tissue sites. Immune competent hosts respond to infection by N. brasiliensis with a rapid and selective development of a profound Th2 immune response that appears able to confer life long protective immunity against reinfection. This review details how the lung can be the site of migrating nematode immune killing and the gut a site of rapid immune mediated clearance of worms. Furthermore it appears that N. brasiliensis induced responses in the lung are sufficient for conferring immunity in lung and gut while infection of the gut only confers immunity in the gut. This review also covers the role of IL-4, STAT6, and the innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin in the generation of CD4-mediated immunity against N. brasiliensis reinfection and discusses what cytokines might be involved in mediated killing or expulsion of helminth parasites.
format Online
Article
Text
id pubmed-3603274
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-36032742013-03-21 Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection Harvie, Marina Camberis, Mali Le Gros, Graham Front Immunol Immunology Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salient features of parasitic worm infection, including parasite development through sequential larval stages as it migrates through specific tissue sites. Immune competent hosts respond to infection by N. brasiliensis with a rapid and selective development of a profound Th2 immune response that appears able to confer life long protective immunity against reinfection. This review details how the lung can be the site of migrating nematode immune killing and the gut a site of rapid immune mediated clearance of worms. Furthermore it appears that N. brasiliensis induced responses in the lung are sufficient for conferring immunity in lung and gut while infection of the gut only confers immunity in the gut. This review also covers the role of IL-4, STAT6, and the innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin in the generation of CD4-mediated immunity against N. brasiliensis reinfection and discusses what cytokines might be involved in mediated killing or expulsion of helminth parasites. Frontiers Media S.A. 2013-03-20 /pmc/articles/PMC3603274/ /pubmed/23518620 http://dx.doi.org/10.3389/fimmu.2013.00074 Text en Copyright © 2013 Harvie, Camberis and Le Gros. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Harvie, Marina
Camberis, Mali
Le Gros, Graham
Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection
title Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection
title_full Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection
title_fullStr Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection
title_full_unstemmed Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection
title_short Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection
title_sort development of cd4 t cell dependent immunity against n. brasiliensis infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603274/
https://www.ncbi.nlm.nih.gov/pubmed/23518620
http://dx.doi.org/10.3389/fimmu.2013.00074
work_keys_str_mv AT harviemarina developmentofcd4tcelldependentimmunityagainstnbrasiliensisinfection
AT camberismali developmentofcd4tcelldependentimmunityagainstnbrasiliensisinfection
AT legrosgraham developmentofcd4tcelldependentimmunityagainstnbrasiliensisinfection