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Dual Phases of Respiration Chain Defect-Augmented mROS-Mediated mCa(2+) Stress during Oxidative Insult in Normal and ρ (0) RBA1 Astrocytes
Mitochondrial respiratory chain (RC) deficits, resulting in augmented mitochondrial ROS (mROS) generation, underlie pathogenesis of astrocytes. However, mtDNA-depleted cells (ρ (0)) lacking RC have been reported to be either sensitive or resistant to apoptosis. In this study, we sought to determine...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603293/ https://www.ncbi.nlm.nih.gov/pubmed/23533684 http://dx.doi.org/10.1155/2013/159567 |