Cargando…

Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities

Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or excessive energy intake that encompasses the linkage of inflammation, oxidation, and metabolism to the deleterious effects associated with the continuous excess of food ingestion. The roles of cytokines an...

Descripción completa

Detalles Bibliográficos
Autores principales: Hernández-Aguilera, Anna, Rull, Anna, Rodríguez-Gallego, Esther, Riera-Borrull, Marta, Luciano-Mateo, Fedra, Camps, Jordi, Menéndez, Javier A., Joven, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603328/
https://www.ncbi.nlm.nih.gov/pubmed/23533299
http://dx.doi.org/10.1155/2013/135698
_version_ 1782263671076945920
author Hernández-Aguilera, Anna
Rull, Anna
Rodríguez-Gallego, Esther
Riera-Borrull, Marta
Luciano-Mateo, Fedra
Camps, Jordi
Menéndez, Javier A.
Joven, Jorge
author_facet Hernández-Aguilera, Anna
Rull, Anna
Rodríguez-Gallego, Esther
Riera-Borrull, Marta
Luciano-Mateo, Fedra
Camps, Jordi
Menéndez, Javier A.
Joven, Jorge
author_sort Hernández-Aguilera, Anna
collection PubMed
description Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or excessive energy intake that encompasses the linkage of inflammation, oxidation, and metabolism to the deleterious effects associated with the continuous excess of food ingestion. The roles of cytokines and insulin resistance in excessive energy intake have been studied extensively. Tobacco use and obesity accompanied by an unhealthy diet and physical inactivity are the main factors that underlie noncommunicable diseases. The implication is that the management of energy or food intake, which is the main role of mitochondria, is involved in the most common diseases. In this study, we highlight the importance of mitochondrial dysfunction in the mutual relationships between causative conditions. Mitochondria are highly dynamic organelles that fuse and divide in response to environmental stimuli, developmental status, and energy requirements. These organelles act to supply the cell with ATP and to synthesise key molecules in the processes of inflammation, oxidation, and metabolism. Therefore, energy sensors and management effectors are determinants in the course and development of diseases. Regulating mitochondrial function may require a multifaceted approach that includes drugs and plant-derived phenolic compounds with antioxidant and anti-inflammatory activities that improve mitochondrial biogenesis and act to modulate the AMPK/mTOR pathway.
format Online
Article
Text
id pubmed-3603328
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36033282013-03-26 Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities Hernández-Aguilera, Anna Rull, Anna Rodríguez-Gallego, Esther Riera-Borrull, Marta Luciano-Mateo, Fedra Camps, Jordi Menéndez, Javier A. Joven, Jorge Mediators Inflamm Review Article Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or excessive energy intake that encompasses the linkage of inflammation, oxidation, and metabolism to the deleterious effects associated with the continuous excess of food ingestion. The roles of cytokines and insulin resistance in excessive energy intake have been studied extensively. Tobacco use and obesity accompanied by an unhealthy diet and physical inactivity are the main factors that underlie noncommunicable diseases. The implication is that the management of energy or food intake, which is the main role of mitochondria, is involved in the most common diseases. In this study, we highlight the importance of mitochondrial dysfunction in the mutual relationships between causative conditions. Mitochondria are highly dynamic organelles that fuse and divide in response to environmental stimuli, developmental status, and energy requirements. These organelles act to supply the cell with ATP and to synthesise key molecules in the processes of inflammation, oxidation, and metabolism. Therefore, energy sensors and management effectors are determinants in the course and development of diseases. Regulating mitochondrial function may require a multifaceted approach that includes drugs and plant-derived phenolic compounds with antioxidant and anti-inflammatory activities that improve mitochondrial biogenesis and act to modulate the AMPK/mTOR pathway. Hindawi Publishing Corporation 2013 2013-02-28 /pmc/articles/PMC3603328/ /pubmed/23533299 http://dx.doi.org/10.1155/2013/135698 Text en Copyright © 2013 Anna Hernández-Aguilera et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hernández-Aguilera, Anna
Rull, Anna
Rodríguez-Gallego, Esther
Riera-Borrull, Marta
Luciano-Mateo, Fedra
Camps, Jordi
Menéndez, Javier A.
Joven, Jorge
Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_full Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_fullStr Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_full_unstemmed Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_short Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_sort mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603328/
https://www.ncbi.nlm.nih.gov/pubmed/23533299
http://dx.doi.org/10.1155/2013/135698
work_keys_str_mv AT hernandezaguileraanna mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT rullanna mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT rodriguezgallegoesther mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT rieraborrullmarta mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT lucianomateofedra mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT campsjordi mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT menendezjaviera mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT jovenjorge mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities