From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part I–Extrapolation of a Covariate Model From Morphine to Zidovudine

New approaches to expedite the development of safe and effective pediatric dosing regimens and first-in-child doses are urgently needed. Model-based approaches require quantitative functions on the maturation of different metabolic pathways. In this study, we directly incorporated a pediatric covari...

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Detalles Bibliográficos
Autores principales: Krekels, E H J, Neely, M, Panoilia, E, Tibboel, D, Capparelli, E, Danhof, M, Mirochnick, M, Knibbe, C A J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603431/
https://www.ncbi.nlm.nih.gov/pubmed/23887364
http://dx.doi.org/10.1038/psp.2012.11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603431/
https://www.ncbi.nlm.nih.gov/pubmed/23887364
http://dx.doi.org/10.1038/psp.2012.11

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