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From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II—Sensitivity to Physiological and Physicochemical Properties

To develop a maturation function for drug glucuronidation in children, that can be used in population and physiologically based modeling approaches, the physiological and physicochemical basis of a semiphysiological glucuronidation function for children was untangled using Simcyp. The results show t...

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Detalles Bibliográficos
Autores principales:	Krekels, E H J, Johnson, T N, den Hoedt, S M, Rostami-Hodjegan, A, Danhof, M, Tibboel, D, Knibbe, C A J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603432/ https://www.ncbi.nlm.nih.gov/pubmed/23887362 http://dx.doi.org/10.1038/psp.2012.12

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