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Exotic mitotic mechanisms

The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope. In this review, we set out the diverse soluti...

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Detalles Bibliográficos
Autores principales: Drechsler, Hauke, McAinsh, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603444/
https://www.ncbi.nlm.nih.gov/pubmed/23271831
http://dx.doi.org/10.1098/rsob.120140
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author Drechsler, Hauke
McAinsh, Andrew D.
author_facet Drechsler, Hauke
McAinsh, Andrew D.
author_sort Drechsler, Hauke
collection PubMed
description The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope. In this review, we set out the diverse solutions that eukaryotic cells use to solve this problem, and show how stepping away from ‘mainstream’ mitosis can teach us much about the mechanisms and mechanics that can drive chromosome segregation. We discuss the evidence for a close functional and physical relationship between membranes, nuclear pores and kinetochores in generating the forces necessary for chromosome segregation during mitosis.
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spelling pubmed-36034442013-03-27 Exotic mitotic mechanisms Drechsler, Hauke McAinsh, Andrew D. Open Biol Review The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope. In this review, we set out the diverse solutions that eukaryotic cells use to solve this problem, and show how stepping away from ‘mainstream’ mitosis can teach us much about the mechanisms and mechanics that can drive chromosome segregation. We discuss the evidence for a close functional and physical relationship between membranes, nuclear pores and kinetochores in generating the forces necessary for chromosome segregation during mitosis. The Royal Society 2012-12 /pmc/articles/PMC3603444/ /pubmed/23271831 http://dx.doi.org/10.1098/rsob.120140 Text en http://creativecommons.org/licenses/by/3.0/ © 2012 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Drechsler, Hauke
McAinsh, Andrew D.
Exotic mitotic mechanisms
title Exotic mitotic mechanisms
title_full Exotic mitotic mechanisms
title_fullStr Exotic mitotic mechanisms
title_full_unstemmed Exotic mitotic mechanisms
title_short Exotic mitotic mechanisms
title_sort exotic mitotic mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603444/
https://www.ncbi.nlm.nih.gov/pubmed/23271831
http://dx.doi.org/10.1098/rsob.120140
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