Cargando…

Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic

Of the 200+ serogroups of Vibrio cholerae, only O1 or O139 strains are reported to cause cholera, and mostly in endemic regions. Cholera outbreaks elsewhere are considered to be via importation of pathogenic strains. Using established animal models, we show that diverse V. cholerae strains indigenou...

Descripción completa

Detalles Bibliográficos
Autores principales: Islam, Atiqul, Labbate, Maurizio, Djordjevic, Steven P., Alam, Munirul, Darling, Aaron, Melvold, Jacqueline, Holmes, Andrew J., Johura, Fatema T., Cravioto, Alejandro, Charles, Ian G., Stokes, H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603452/
https://www.ncbi.nlm.nih.gov/pubmed/23407641
http://dx.doi.org/10.1098/rsob.120181
_version_ 1782263684412735488
author Islam, Atiqul
Labbate, Maurizio
Djordjevic, Steven P.
Alam, Munirul
Darling, Aaron
Melvold, Jacqueline
Holmes, Andrew J.
Johura, Fatema T.
Cravioto, Alejandro
Charles, Ian G.
Stokes, H. W.
author_facet Islam, Atiqul
Labbate, Maurizio
Djordjevic, Steven P.
Alam, Munirul
Darling, Aaron
Melvold, Jacqueline
Holmes, Andrew J.
Johura, Fatema T.
Cravioto, Alejandro
Charles, Ian G.
Stokes, H. W.
author_sort Islam, Atiqul
collection PubMed
description Of the 200+ serogroups of Vibrio cholerae, only O1 or O139 strains are reported to cause cholera, and mostly in endemic regions. Cholera outbreaks elsewhere are considered to be via importation of pathogenic strains. Using established animal models, we show that diverse V. cholerae strains indigenous to a non-endemic environment (Sydney, Australia), including non-O1/O139 serogroup strains, are able to both colonize the intestine and result in fluid accumulation despite lacking virulence factors believed to be important. Most strains lacked the type three secretion system considered a mediator of diarrhoea in non-O1/O13 V. cholerae. Multi-locus sequence typing (MLST) showed that the Sydney isolates did not form a single clade and were distinct from O1/O139 toxigenic strains. There was no correlation between genetic relatedness and the profile of virulence-associated factors. Current analyses of diseases mediated by V. cholerae focus on endemic regions, with only those strains that possess particular virulence factors considered pathogenic. Our data suggest that factors other than those previously well described are of potential importance in influencing disease outbreaks.
format Online
Article
Text
id pubmed-3603452
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-36034522013-03-27 Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic Islam, Atiqul Labbate, Maurizio Djordjevic, Steven P. Alam, Munirul Darling, Aaron Melvold, Jacqueline Holmes, Andrew J. Johura, Fatema T. Cravioto, Alejandro Charles, Ian G. Stokes, H. W. Open Biol Research Of the 200+ serogroups of Vibrio cholerae, only O1 or O139 strains are reported to cause cholera, and mostly in endemic regions. Cholera outbreaks elsewhere are considered to be via importation of pathogenic strains. Using established animal models, we show that diverse V. cholerae strains indigenous to a non-endemic environment (Sydney, Australia), including non-O1/O139 serogroup strains, are able to both colonize the intestine and result in fluid accumulation despite lacking virulence factors believed to be important. Most strains lacked the type three secretion system considered a mediator of diarrhoea in non-O1/O13 V. cholerae. Multi-locus sequence typing (MLST) showed that the Sydney isolates did not form a single clade and were distinct from O1/O139 toxigenic strains. There was no correlation between genetic relatedness and the profile of virulence-associated factors. Current analyses of diseases mediated by V. cholerae focus on endemic regions, with only those strains that possess particular virulence factors considered pathogenic. Our data suggest that factors other than those previously well described are of potential importance in influencing disease outbreaks. The Royal Society 2013-02 /pmc/articles/PMC3603452/ /pubmed/23407641 http://dx.doi.org/10.1098/rsob.120181 Text en http://creativecommons.org/licenses/by/3.0/ © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Research
Islam, Atiqul
Labbate, Maurizio
Djordjevic, Steven P.
Alam, Munirul
Darling, Aaron
Melvold, Jacqueline
Holmes, Andrew J.
Johura, Fatema T.
Cravioto, Alejandro
Charles, Ian G.
Stokes, H. W.
Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic
title Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic
title_full Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic
title_fullStr Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic
title_full_unstemmed Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic
title_short Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic
title_sort indigenous vibrio cholerae strains from a non-endemic region are pathogenic
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603452/
https://www.ncbi.nlm.nih.gov/pubmed/23407641
http://dx.doi.org/10.1098/rsob.120181
work_keys_str_mv AT islamatiqul indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT labbatemaurizio indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT djordjevicstevenp indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT alammunirul indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT darlingaaron indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT melvoldjacqueline indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT holmesandrewj indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT johurafatemat indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT craviotoalejandro indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT charlesiang indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic
AT stokeshw indigenousvibriocholeraestrainsfromanonendemicregionarepathogenic