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Modeling Interindividual Variability in Physiologically Based Pharmacokinetics and Its Link to Mechanistic Covariate Modeling

Covariate modeling is a key step in the analysis of clinical data and is essential for establishing dosing recommendations for specific populations, e.g., in obese individuals and children. So far, no systematic approach exists to leverage the knowledge inherent in physiologically based pharmacokine...

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Detalles Bibliográficos
Autores principales:	Huisinga, W, Solms, A, Fronton, L, Pilari, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603474/ https://www.ncbi.nlm.nih.gov/pubmed/23835884 http://dx.doi.org/10.1038/psp.2012.3

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