Cargando…
Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report
Cerebral palsy is the most common motor disability in childhood. In current paper, we first report our clinical data regarding administration of umbilical cord mesenchymal stem cells (MSCs) transplantation in treatment of cerebral palsy. A 5-year-old girl with cerebral palsy was treated with multipl...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603664/ https://www.ncbi.nlm.nih.gov/pubmed/23533920 http://dx.doi.org/10.1155/2013/146347 |
_version_ | 1782263708490137600 |
---|---|
author | Wang, Liming Ji, Haijie Zhou, Jianjun Xie, Jiang Zhong, Zhanqiang Li, Ming Bai, Wen Li, Na Zhang, Zijia Wang, Xuejun Zhu, Delin Liu, Yongjun Wu, Mingyuan |
author_facet | Wang, Liming Ji, Haijie Zhou, Jianjun Xie, Jiang Zhong, Zhanqiang Li, Ming Bai, Wen Li, Na Zhang, Zijia Wang, Xuejun Zhu, Delin Liu, Yongjun Wu, Mingyuan |
author_sort | Wang, Liming |
collection | PubMed |
description | Cerebral palsy is the most common motor disability in childhood. In current paper, we first report our clinical data regarding administration of umbilical cord mesenchymal stem cells (MSCs) transplantation in treatment of cerebral palsy. A 5-year-old girl with cerebral palsy was treated with multiple times of intravenous and intrathecal administration of MSCs derived from her young sister and was followed up for 28 months. The gross motor dysfunction was improved. Other benefits included enhanced immunity, increased physical strength, and adjusted speech and comprehension. Temporary low-grade fever was the only side effect during the treatment. MSCs may be a safe and effective therapy to improve symptoms in children with cerebral palsy. |
format | Online Article Text |
id | pubmed-3603664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36036642013-03-26 Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report Wang, Liming Ji, Haijie Zhou, Jianjun Xie, Jiang Zhong, Zhanqiang Li, Ming Bai, Wen Li, Na Zhang, Zijia Wang, Xuejun Zhu, Delin Liu, Yongjun Wu, Mingyuan Case Rep Transplant Case Report Cerebral palsy is the most common motor disability in childhood. In current paper, we first report our clinical data regarding administration of umbilical cord mesenchymal stem cells (MSCs) transplantation in treatment of cerebral palsy. A 5-year-old girl with cerebral palsy was treated with multiple times of intravenous and intrathecal administration of MSCs derived from her young sister and was followed up for 28 months. The gross motor dysfunction was improved. Other benefits included enhanced immunity, increased physical strength, and adjusted speech and comprehension. Temporary low-grade fever was the only side effect during the treatment. MSCs may be a safe and effective therapy to improve symptoms in children with cerebral palsy. Hindawi Publishing Corporation 2013 2013-03-03 /pmc/articles/PMC3603664/ /pubmed/23533920 http://dx.doi.org/10.1155/2013/146347 Text en Copyright © 2013 Liming Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Wang, Liming Ji, Haijie Zhou, Jianjun Xie, Jiang Zhong, Zhanqiang Li, Ming Bai, Wen Li, Na Zhang, Zijia Wang, Xuejun Zhu, Delin Liu, Yongjun Wu, Mingyuan Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report |
title | Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report |
title_full | Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report |
title_fullStr | Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report |
title_full_unstemmed | Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report |
title_short | Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report |
title_sort | therapeutic potential of umbilical cord mesenchymal stromal cells transplantation for cerebral palsy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603664/ https://www.ncbi.nlm.nih.gov/pubmed/23533920 http://dx.doi.org/10.1155/2013/146347 |
work_keys_str_mv | AT wangliming therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT jihaijie therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT zhoujianjun therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT xiejiang therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT zhongzhanqiang therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT liming therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT baiwen therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT lina therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT zhangzijia therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT wangxuejun therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT zhudelin therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT liuyongjun therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport AT wumingyuan therapeuticpotentialofumbilicalcordmesenchymalstromalcellstransplantationforcerebralpalsyacasereport |