Cargando…

Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) is one of the world's top ten most common cancers. Current survival rates are poor with only 50% of patients expected to survive five years after diagnosis. The poor survival rate of HNSCC is partly attributable to the tendency for diagnosis at the...

Descripción completa

Detalles Bibliográficos
Autores principales: Major, Aidan G., Pitty, Luke P., Farah, Camile S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603684/
https://www.ncbi.nlm.nih.gov/pubmed/23533441
http://dx.doi.org/10.1155/2013/319489
_version_ 1782263712341557248
author Major, Aidan G.
Pitty, Luke P.
Farah, Camile S.
author_facet Major, Aidan G.
Pitty, Luke P.
Farah, Camile S.
author_sort Major, Aidan G.
collection PubMed
description Head and neck squamous cell carcinoma (HNSCC) is one of the world's top ten most common cancers. Current survival rates are poor with only 50% of patients expected to survive five years after diagnosis. The poor survival rate of HNSCC is partly attributable to the tendency for diagnosis at the late stage of the disease. One of the reasons for treatment failure is thought to be related to the presence of a subpopulation of cells within the tumour called cancer stem cells (CSCs). CSCs display stem cell-like characteristics that impart resistance to conventional treatment modalities and promote tumour initiation, progression, and metastasis. Specific markers for this population have been investigated in the hope of developing a deeper understanding of their role in the pathogenesis of HNSCC and elucidating novel therapeutic strategies.
format Online
Article
Text
id pubmed-3603684
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36036842013-03-26 Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma Major, Aidan G. Pitty, Luke P. Farah, Camile S. Stem Cells Int Review Article Head and neck squamous cell carcinoma (HNSCC) is one of the world's top ten most common cancers. Current survival rates are poor with only 50% of patients expected to survive five years after diagnosis. The poor survival rate of HNSCC is partly attributable to the tendency for diagnosis at the late stage of the disease. One of the reasons for treatment failure is thought to be related to the presence of a subpopulation of cells within the tumour called cancer stem cells (CSCs). CSCs display stem cell-like characteristics that impart resistance to conventional treatment modalities and promote tumour initiation, progression, and metastasis. Specific markers for this population have been investigated in the hope of developing a deeper understanding of their role in the pathogenesis of HNSCC and elucidating novel therapeutic strategies. Hindawi Publishing Corporation 2013 2013-03-03 /pmc/articles/PMC3603684/ /pubmed/23533441 http://dx.doi.org/10.1155/2013/319489 Text en Copyright © 2013 Aidan G. Major et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Major, Aidan G.
Pitty, Luke P.
Farah, Camile S.
Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma
title Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma
title_full Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma
title_fullStr Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma
title_short Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma
title_sort cancer stem cell markers in head and neck squamous cell carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603684/
https://www.ncbi.nlm.nih.gov/pubmed/23533441
http://dx.doi.org/10.1155/2013/319489
work_keys_str_mv AT majoraidang cancerstemcellmarkersinheadandnecksquamouscellcarcinoma
AT pittylukep cancerstemcellmarkersinheadandnecksquamouscellcarcinoma
AT farahcamiles cancerstemcellmarkersinheadandnecksquamouscellcarcinoma