Cargando…

A Pilot Study to Investigate the Role of Thymidylate Synthase as a Marker of Prognosis for Neoadjuvant Chemotherapy in Gastric and Gastro-Oesophageal Junction Adenocarcinoma

Aims and Background. Patients in the United Kingdom with operable gastric and gastro-oesophageal junction (GOJ) tumours receive neoadjuvant chemotherapy. Our aim was to study the expression of thymidylate synthase (TS) enzyme in pre-treatment diagnostic biopsy specimens and investigate its clinical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mirza, A., Brown, M., McNulty, C., Valentine, J., Annesley, A., Galloway, S., Welch, I., West, C. M., Pritchard, S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603715/ https://www.ncbi.nlm.nih.gov/pubmed/23533389 http://dx.doi.org/10.1155/2013/502153

Ejemplares similares

Emerging aspects of oesophageal and gastro-oesophageal junction cancer histopathology – an update for the surgical oncologist
por: Griffiths, Ewen A, et al.
Publicado: (2006)

The Evolution of Neo-Adjuvant Therapy in the Treatment of Oesophageal and Gastro-Oesophageal Junction Adenocarcinomas
por: Dermanis, Alexander A., et al.
Publicado: (2023)

Safety and feasibility of preoperative exercise training during neoadjuvant treatment before surgery for adenocarcinoma of the gastro‐oesophageal junction
por: Christensen, J. F., et al.
Publicado: (2018)

Impact of postoperative TNM stages after neoadjuvant therapy on prognosis of adenocarcinoma of the gastro-oesophageal junction tumours
por: Thomaschewski, Michael, et al.
Publicado: (2018)

Total neoadjuvant chemotherapy with FLOT scheme in resectable adenocarcinoma of the gastro-oesophageal junction or gastric adenocarcinoma: impact on pathological complete response and safety
por: Villanueva, Luis, et al.
Publicado: (2021)

Enduring complete metabolic response in metastatic adenocarcinoma of the gastro-oesophageal junction
por: Li, Minmin, et al.
Publicado: (2014)

Hypoxia-inducible factor-1α expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas
por: Griffiths, E A, et al.
Publicado: (2007)

Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis
por: Griffiths, E A, et al.
Publicado: (2008)

The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction
por: Curtis, Nathan J, et al.
Publicado: (2014)

Combined Therapy of Locally Advanced Oesophageal and Gastro–Oesophageal Junction Adenocarcinomas: State of the Art and Aspects of Predictive Factors
por: Vošmik, Milan, et al.
Publicado: (2021)

Significance of tumour regression in lymph node metastases of gastric and gastro‐oesophageal junction adenocarcinomas
por: Reim, Daniel, et al.
Publicado: (2020)

Minimally invasive surgery for gastro-oesophageal junction adenocarcinoma: Current evidence and future perspectives
por: Bîrlă, Rodica, et al.
Publicado: (2023)

Carcinoma of gastro-oesophageal junction in a pregnant woman
por: Kozak, Katarzyna, et al.
Publicado: (2018)

Economic evaluation of FLOT and ECF/ECX perioperative chemotherapy in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma
por: Zeng, Hanqing, et al.
Publicado: (2022)

Thymidylate Synthase Genotype-Directed Chemotherapy for Patients with Gastric and Gastroesophageal Junction Cancers
por: Goff, Laura W., et al.
Publicado: (2014)

Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma
por: Propper, David, et al.
Publicado: (2016)

Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction
por: D'Errico, A, et al.
Publicado: (2000)

Neoplastic and pre-neoplastic lesions of the oesophagus and gastro-oesophageal junction
por: Grillo, Federica, et al.
Publicado: (2020)

A phase II trial of preoperative chemotherapy with epirubicin, cisplatin and capecitabine for patients with localised gastro-oesophageal junctional adenocarcinoma
por: Starling, N, et al.
Publicado: (2009)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas
por: Bain, G H, et al.
Publicado: (2014)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas
por: Bain, G H, et al.
Publicado: (2015)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas
por: Bain, G H, et al.
Publicado: (2016)

Dose-escalated neoadjuvant chemoradiotherapy for locally advanced oesophageal or oesophagogastric junctional adenocarcinoma
por: Duque-Santana, Victor, et al.
Publicado: (2022)

Epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF) as neoadjuvant chemotherapy in gastro-oesophageal cancer.
por: Melcher, A. A., et al.
Publicado: (1996)

The Postoperative Component of MAGIC Chemotherapy Is Associated with Improved Prognosis following Surgical Resection in Gastric and Gastrooesophageal Junction Adenocarcinomas
por: Mirza, A., et al.
Publicado: (2013)

Gastro-Œsophageal Intussusception
Publicado: (1935)

Adenocarcinoma of oesophagus involving gastro-oesophageal junction following mini-gastric bypass/ one anastomosis gastric bypass
por: Aggarwal, Sandeep, et al.
Publicado: (2020)

Significance of thymidylate synthase expression for resistance to pemetrexed in pulmonary adenocarcinoma
por: YANG, MIN, et al.
Publicado: (2014)

Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase
por: Chaianantakul, Natpasit, et al.
Publicado: (2013)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas
por: Shorthouse, David, et al.
Publicado: (2023)

Snoring induced reflux (SnoR) and a carcinoma in the gastro-oesophageal junction
por: Loske, Gunnar
Publicado: (2022)

Impact on postoperative complications of changes in skeletal muscle mass during neoadjuvant chemotherapy for gastro‐oesophageal cancer
por: den Boer, R. B., et al.
Publicado: (2020)

Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction
por: Wainberg, Z A, et al.
Publicado: (2011)

EGFR gene amplification is relatively common and associates with outcome in intestinal adenocarcinoma of the stomach, gastro-oesophageal junction and distal oesophagus
por: Birkman, Eva-Maria, et al.
Publicado: (2016)

Quality assurance of surgery in the randomized ST03 trial of perioperative chemotherapy in carcinoma of the stomach and gastro‐oesophageal junction
por: Allum, W. H., et al.
Publicado: (2019)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

Predictive value of thymidylate synthase for the prognosis and survival of lung adenocarcinoma patients
por: HUANG, YAN, et al.
Publicado: (2015)

Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastro-oesophageal junction adenocarcinoma (DOCETUX study)
por: Pinto, C, et al.
Publicado: (2009)

Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction
por: Sugano, Kentaro, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s60395inpa9ks72r1c2hce3kef