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Differential Pre-mRNA Splicing Regulates Nnat Isoforms in the Hypothalamus after Gastric Bypass Surgery in Mice

BACKGROUND: Neuronatin (NNAT) is an endoplasmic reticulum proteolipid implicated in intracellular signalling. Nnat is highly-expressed in the hypothalamus, where it is acutely regulated by nutrients and leptin. Nnat pre-mRNA is differentially spliced to create Nnat-α and -β isoforms. Genetic variati...

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Detalles Bibliográficos
Autores principales:	Scott, William R., Gelegen, Cigdem, Chandarana, Keval, Karra, Efthimia, Yousseif, Ahmed, Amouyal, Chloé, Choudhury, Agharul I., Andreelli, Fabrizio, Withers, Dominic J., Batterham, Rachel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603916/ https://www.ncbi.nlm.nih.gov/pubmed/23527188 http://dx.doi.org/10.1371/journal.pone.0059407

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