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Insight the C-Site Pocket Conformational Changes Responsible for Sirtuin 2 Activity Using Molecular Dynamics Simulations

Sirtuin belongs to a family of typical histone deacetylase which regulates the fundamental cellular biological processes including gene expression, genome stability, mitosis, nutrient metabolism, aging, mitochondrial function, and cell motility. Michael et. al. reported that B-site mutation (Q167A a...

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Detalles Bibliográficos
Autores principales:	Sakkiah, Sugunadevi, Arooj, Mahreen, Cao, Guang Ping, Lee, Keun Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603925/ https://www.ncbi.nlm.nih.gov/pubmed/23527151 http://dx.doi.org/10.1371/journal.pone.0059278

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