Cargando…

Activating Somatic FGFR2 Mutations in Breast Cancer

It is known that FGFR2 gene variations confer a risk for breast cancer. FGFR2 and FGF10, the main ligand of FGFR2, are both overexpressed in 5–10% of breast tumors. In our study, we sequenced the most important coding regions of FGFR2 in somatic tumor tissue of 140 sporadic breast cancer patients an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reintjes, Nadine, Li, Yun, Becker, Alexandra, Rohmann, Edyta, Schmutzler, Rita, Wollnik, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603931/ https://www.ncbi.nlm.nih.gov/pubmed/23527311 http://dx.doi.org/10.1371/journal.pone.0060264

Ejemplares similares

Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy
por: Yang, Zhao, et al.
Publicado: (2018)

Activating FGFR1 Mutations in Sporadic Pheochromocytomas
por: Welander, Jenny, et al.
Publicado: (2017)

Somatic Mutations in Breast Cancer: The Tip of the Iceberg
por: Park, Jung Ho, et al.
Publicado: (2022)

RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations
por: Subbiah, Vivek, et al.
Publicado: (2023)

G388R mutation of the FGFR4 gene is not relevant to breast cancer prognosis
por: Jézéquel, P, et al.
Publicado: (2004)

Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer
por: Malchers, Florian, et al.
Publicado: (2023)

FGFR2 genetic variants in women with breast cancer
por: Dix-Peek, Thérèse, et al.
Publicado: (2023)

Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4
por: Marks, Jenifer L., et al.
Publicado: (2007)

In Vitro and In Vivo Activity of Lucitanib in FGFR1/2 Amplified or Mutated Cancer Models()()
por: Guffanti, Federica, et al.
Publicado: (2016)

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
por: Shlien, Adam, et al.
Publicado: (2016)

Proteogenomics connects somatic mutations to signaling in breast cancer
por: Mertins, Philipp, et al.
Publicado: (2016)

Somatic mutations in early onset luminal breast cancer
por: Encinas, Giselly, et al.
Publicado: (2018)

Somatic mutations in leukocytes infiltrating primary breast cancers
por: Kleppe, Maria, et al.
Publicado: (2015)

Germline and Somatic mutations in postmenopausal breast cancer patients
por: Nagy, Tauana Rodrigues, et al.
Publicado: (2021)

Novel mutation detection of fibroblast growth factor receptor 1 (FGFR1) gene, FGFR2IIIa, FGFR2IIIb, FGFR2IIIc, FGFR3, FGFR4 gene for craniosynostosis: A prospective study in Asian Indian patient
por: Barik, Mayadhar, et al.
Publicado: (2015)

Mutational Landscapes and Phenotypic Spectrum of SWI/SNF-Related Intellectual Disability Disorders
por: Bögershausen, Nina, et al.
Publicado: (2018)

Analysis of 30 Putative BRCA1 Splicing Mutations in Hereditary Breast and Ovarian Cancer Families Identifies Exonic Splice Site Mutations That Escape In Silico Prediction
por: Wappenschmidt, Barbara, et al.
Publicado: (2012)

FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype
por: Levine, Kevin M., et al.
Publicado: (2019)

Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma
por: Fomchenko, Elena I., et al.
Publicado: (2021)

Association of FGFR3 and FGFR4 gene polymorphisms with breast cancer in Chinese women of Heilongjiang province
por: Jiang, Yongdong, et al.
Publicado: (2015)

FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells
por: Zhao, Ming, et al.
Publicado: (2019)

Master regulators of FGFR2 signalling and breast cancer risk
por: Fletcher, Michael N. C., et al.
Publicado: (2013)

Germline and somatic mosaicism for FGFR2 mutation in the mother of a child with Crouzon syndrome: Implications for genetic testing in “paternal age-effect” syndromes
por: Goriely, Anne, et al.
Publicado: (2010)

Somatic mutation analysis of MYH11 in breast and prostate cancer
por: Alhopuro, Pia, et al.
Publicado: (2008)

The prognostic effects of somatic mutations in ER-positive breast cancer
por: Griffith, Obi L., et al.
Publicado: (2018)

Association of Body Mass Index With Somatic Mutations in Breast Cancer
por: Chen, Bo, et al.
Publicado: (2021)

Characterization of AKT Somatic Mutations in Chinese Breast Cancer Patients
por: Wen, Lingzhu, et al.
Publicado: (2021)

Significance of the FGFR3 mutation in Chinese patients with bladder cancer
por: Hao, Lanxiang, et al.
Publicado: (2023)

FGFR1 is an adverse outcome indicator for luminal A breast cancers
por: Shi, Yu-Jie, et al.
Publicado: (2015)

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use
por: Patani, Harshnira, et al.
Publicado: (2016)

Low Incidence of Germline and Somatic Alterations in the E-Cadherin Gene in Lobular Breast Carcinoma
por: Schmutzler, R. K., et al.
Publicado: (1999)

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR
por: Lu, Hengyu, et al.
Publicado: (2020)

Somatic mutations in benign breast disease tissues and association with breast cancer risk
por: Winham, Stacey J., et al.
Publicado: (2021)

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases
por: Zhang, Yun, et al.
Publicado: (2018)

Correction: FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells
por: Zhao, Ming, et al.
Publicado: (2019)

New gain-of-function mutation shows CACNA1D as recurrently mutated gene in autism spectrum disorders and epilepsy
por: Pinggera, Alexandra, et al.
Publicado: (2017)

Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrum
por: Schmidt, Julia, et al.
Publicado: (2022)

Germline PALB2 Mutations in Cancers and Its Distinction From Somatic PALB2 Mutations in Breast Cancers
por: Hu, Zhe-Yu, et al.
Publicado: (2020)

Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
por: Facchinetti, Francesco, et al.
Publicado: (2023)

Intrinsic FGFR2 and Ectopic FGFR1 Signaling in the Prostate and Prostate Cancer
por: Wang, Cong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rvjfp4cnbi7fo1hpa8cibqo7r1